Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.075
Abstract: Phenelzine was first employed to design new aryl hydrazine-based LSD1 inhibitors based on the experience-based discovery (EBD) strategy. Among these compounds, D8 potently inhibited LSD1 (IC50 = 882.30 nM) in a reversible manner. Compound D8 was selective to… read more here.
Keywords: based discovery; aryl hydrazines; experience based; hydrazines new ... See more keywords
Experience-based learning during the final year – quantitative content analyses of students’ self-reports
Sign Up to like & getrecommendations! Published in 2022 at "Medical Teacher"
DOI: 10.1080/0142159x.2022.2144187
Abstract: Abstract Purpose The final year offers students the opportunity to explore their future role as a physician in different environments. Learning success depends in large part on how students experience these assignments. The aim of… read more here.
Keywords: experience based; year; final year; based learning ... See more keywords
Clinical practice enhanced by interdisciplinary theoretical perspectives
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DOI: 10.1080/02813432.2024.2368852
Abstract: Abstract Background Experience-based knowing in general practice includes advanced interpretation of subjective, complex and particular phenomena in a social context. Enabling different metapositions for reflexivity may provide the accountability needed for such knowing to be… read more here.
Keywords: substantive theories; practice; experience based; general practice ... See more keywords
Let’s ROC: a dynamic experience-based roadmap for relational engagement
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DOI: 10.1108/ejm-04-2024-0333
Abstract: This paper aims to provide researchers with an experience-based roadmap for relational engagement which illustrates how to scale from small impacts to larger ones. Although the relational engagement approach is still nascent and unfolding, it… read more here.
Keywords: relational engagement; experience based; based roadmap; paper ... See more keywords
Using the experience‐based co‐design method to design a teaching package
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DOI: 10.1111/medu.13720
Abstract: What problems were addressed? The World Health Organization recommends average noise levels in patient care areas no higher than 35 dB, with peaks below 40 dB. In reality, most intensive care units (ICUs) worldwide average… read more here.
Keywords: staff; experience based; design method; based design ... See more keywords
Experience-based learning: an alternative approach to teaching medical students on paediatric placements
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2021-322077
Abstract: Paediatric placements provide medical student’ main undergraduate training in caring for children and young people. Yet changes in medical education have reduced opportunities to participate in patient care, potentially leading students to feel underprepared for… read more here.
Keywords: experience based; paediatric placements; based learning; teaching medical ... See more keywords
Visual Experience-Based Question Answering with Complex Multimodal Environments
Sign Up to like & getrecommendations! Published in 2020 at "Mathematical Problems in Engineering"
DOI: 10.1155/2020/8567271
Abstract: This paper proposes a novel visual experience-based question answering problem (VEQA) and the corresponding dataset for embodied intelligence research that requires an agent to do actions, understand 3D scenes from successive partial input images, and… read more here.
Keywords: experience based; question; complex multimodal; visual experience ... See more keywords
Abstract P4-04-09: Supporting the Knowledge Translation of Exercise Recommendations for People with Bone Metastases using Experience-based Co-Design
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p4-04-09
Abstract: Background: Historically, people with bone metastases have been advised to limit exercise due to the risk of adverse events, such as fractures. In 2022, the International Bone Metastases Exercise Working Group published evidence-informed recommendations indicating… read more here.
Keywords: knowledge; experience based; people bone; bone metastases ... See more keywords
International comparison of experience-based health state values at the population level
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DOI: 10.1186/s12955-017-0694-9
Abstract: BackgroundDecision makers need to know whether health state values, an important component of summary measures of health, are valid for their target population. A key outcome is the individuals’ valuation of their current health. This… read more here.
Keywords: health; health state; state values; experience based ... See more keywords
Nonlinear identification of Bouc-Wen hysteretic parameters using improved experience-based learning algorithm
Sign Up to like & getrecommendations! Published in 2020 at "Structural Engineering and Mechanics"
DOI: 10.12989/sem.2020.76.1.101
Abstract: In this paper, an improved experience-based learning algorithm (EBL), termed as IEBL, is proposed to solve the nonlinear hysteretic parameter identification problem with Bouc-Wen model. A quasi-opposition-based learning mechanism and new updating equations are introduced… read more here.
Keywords: bouc wen; improved experience; based learning; learning algorithm ... See more keywords
Experience-based co-design (EBCD) with young people who offend: Innovating methodology to reach marginalised groups
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DOI: 10.1371/journal.pone.0270782
Abstract: The mental health needs of young people who offend have become more widely recognised and attempting to meet these needs is now a global priority for governments and health agencies. Young people who offend experience… read more here.
Keywords: young people; experience based; people offend; methodology ... See more keywords