Th17 cells and their cytokines serve as potential therapeutic target in experimental autoimmune neuritis
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1478
Abstract: Accumulating evidence has pointed that T helper 17 cells and their cytokines are pathogenic in Guillain–Barré syndrome (GBS). However, little is known concerning the IL‐17 expression change trend during the whole course of disease, and… read more here.
Keywords: experimental autoimmune; cells cytokines; th17 cells; autoimmune neuritis ... See more keywords
Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2965
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated disease that targets the myelin sheaths of the peripheral nerves. Fingolimod is a sphingosine 1 phosphate (S1P) receptor antagonist with a high affinity for S1P receptors through… read more here.
Keywords: autoimmune neuritis; chronic experimental; experimental autoimmune; ameliorates chronic ... See more keywords
BJ‐2266 ameliorates experimental autoimmune encephalomyelitis through down‐regulation of the JAK/STAT signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646860
Abstract: CD4+ T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro‐environmental factors present during T‐cell priming, direct differentiation of naïve CD4+ T cells into pro‐inflammatory Th1 and Th17 cells. From extensive screening… read more here.
Keywords: cd4 cells; jak stat; differentiation; autoimmune encephalomyelitis ... See more keywords
S1P receptor antagonists fingolimod and siponimod do not improve the outcome of experimental autoimmune myasthenia gravis mice after disease onset
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747187
Abstract: Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatigue in the presence of circulating antibodies against components of the neuromuscular junction. Most patients have a good prognosis, but some are refractory… read more here.
Keywords: experimental autoimmune; autoimmune myasthenia; myasthenia gravis; fingolimod siponimod ... See more keywords
MicroRNA 182 promotes T helper 1 cell by repressing hypoxia induced factor 1 alpha in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948111
Abstract: MicroRNA 182 is important for the clonal expansion of CD4+ T cells (Th) following IL‐2 stimulation and is a potential therapeutic target for autoimmune diseases. In the present study, we investigated the role of microRNA… read more here.
Keywords: autoimmune encephalomyelitis; microrna 182; helper cell; cd4 ... See more keywords
B cell modulation with anti-CD79bantibodies ameliorates experimental autoimmune encephalitis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149523
Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like multiple sclerosis, rheumatoid arthritis or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for multiple… read more here.
Keywords: autoimmune encephalitis; cell modulation; experimental autoimmune; cell ... See more keywords
Antigen clearance at the peak of the primary immune response induces experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250122
Abstract: Autoimmune demyelinating diseases can be induced by an immune response against myelin peptides; however, the exact mechanism underlying the development of such diseases remains unclear. In experimental autoimmune encephalomyelitis, we found that the clearance of… read more here.
Keywords: experimental autoimmune; effector cells; antigen; immune response ... See more keywords
Retracted: Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23257
Abstract: Following on from the Expression of Concern (10.1002/glia.22466) previously published by GLIA, the following Original Article has been retracted by the journal Editors and Publisher: read more here.
Keywords: role experimental; metallothionein expression; expression role; expression ... See more keywords
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27792
Abstract: Multiple sclerosis (MS) is a highly disabling demyelinating disease, which mainly affects young adults and is difficult to cure. Activated microglia may be involved in the process of neuronal cell damage and release inflammatory cytokines… read more here.
Keywords: multiple sclerosis; autoimmune encephalomyelitis; experimental autoimmune;
Dose‐dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25007
Abstract: Female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive… read more here.
Keywords: dose dependent; experimental autoimmune; visual function; autoimmune encephalomyelitis ... See more keywords
Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_26
Abstract: The protocol in this chapter presents a method to actively induce experimental autoimmune encephalomyelitis (EAE), one of the most widely used animal models to study efficacy of potential drugs for treatment of multiple sclerosis. Multiple… read more here.
Keywords: autoimmune encephalomyelitis; experimental autoimmune; c57bl mice;