Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1207-y
Abstract: Objective and designProtease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.MethodEffects of Malt1 protease on the activation of… read more here.
Keywords: th17 th1; th1 cells; malt1; colitis ... See more keywords
Effect of sumatriptan on acetic acid-induced experimental colitis in rats: a possible role for the 5-HT1B/1D receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-022-02215-5
Abstract: Mucosal inflammation in colitis is associated with changes in the intestinal serotonin (5-HT) level. Sumatriptan, a 5-HT1B/1D receptor agonist, has demonstrated anti-inflammatory characteristics. The purpose of this study was to determine the effects of sumatriptan… read more here.
Keywords: experimental colitis; colitis; ht1b receptors; acetic acid ... See more keywords
Amelioration of murine experimental colitis using biocompatible cyclosporine A lipid carriers
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00835-z
Abstract: Lipoproteins are biodegradable and biocompatible natural carriers that can be utilized for the transport of hydrophobic drugs, such as cyclosporin A (CycloA), a calcineurin inhibitor utilized for the inflammatory bowel disease, such as ulcerative colitis.… read more here.
Keywords: murine experimental; drug; colitis; colitis using ... See more keywords
Activated Hepatic Nuclear Factor-κB in Experimental Colitis Regulates CYP2A5 and Metronidazole Disposition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00890
Abstract: Systemic exposure of metronidazole is increased in patients with inflammatory bowel diseases (IBDs), while the underlying mechanism remains unknown. Here, we aim to decipher the mechanisms by which experimental colitis regulates metronidazole disposition in mice.… read more here.
Keywords: metronidazole disposition; colitis regulates; colitis; experimental colitis ... See more keywords
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0413-7
Abstract: Dipeptidyl peptidase 4 (DPP4), a ubiquitously expressed protease that cleaves off the N-terminal dipeptide from proline and alanine on the penultimate position, has important roles in many physiological processes. In the present study, experimental colitis… read more here.
Keywords: sitagliptin; dss induced; glp; colitis ... See more keywords
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13046-3
Abstract: Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor cells. In other cell types, including immune… read more here.
Keywords: colitis; cibinetide; mice; course experimental ... See more keywords
Effect of Infliximab and Adalimumab on Experimental Colitis Following Orally Supplemented Iron
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2016.1215574
Abstract: ABSTRACT Background: Orally administered iron can induce colonic inflammation in healthy animals and aggravate experimental colitis. Aim: To investigate the influence of the biologic agents infliximab and adalimumab on the severity of TNBS colitis following… read more here.
Keywords: following orally; colitis; colitis following; infliximab adalimumab ... See more keywords
Fusobacterium nucleatum Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac177
Abstract: BACKGROUND Ulcerative colitis (UC) may be exacerbated by Fusobacterium nucleatum (Fn) infection. However, the mechanism underlying Fn-mediated progression of UC has yet to be established. Here, we aimed to establish whether and how Fn-derived extracellular… read more here.
Keywords: mir 574; colitis; 574 card3; fusobacterium nucleatum ... See more keywords
Syndecan-4 Modulates Epithelial Gut Barrier Function and Epithelial Regeneration in Experimental Colitis.
Sign Up to like & getrecommendations! Published in 2018 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izy248
Abstract: Background The transmembrane heparan sulfate proteoglycan Syndecan-4 (Sdc4) plays an important role in the regulation of various inflammatory disorders. However, the involvement of Sdc4 in intestinal inflammation remains unknown. Therefore, we assessed the impact of… read more here.
Keywords: wound healing; sdc4; regeneration; colitis ... See more keywords
Therapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics
Sign Up to like & getrecommendations! Published in 2023 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s399290
Abstract: Background Baicalin is an important active flavonoid isolated from the roots of Scutellaria baicalensis (S. baicalensis), a well-known traditional Chinese herb used in treating inflammatory bowel disease (IBD). The objectives of this study were to… read more here.
Keywords: pharmacology; experimental colitis; network pharmacology; baicalin experimental ... See more keywords
Multi-Omics Analysis of Western-style Diet Increased Susceptibility to Experimental Colitis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s361039
Abstract: Background Western-style diet (WSD) is associated with inflammatory bowel disease (IBD) prevalence. However, the impact of WSD on IBD development and its underlying mechanism remain unclear. Transcriptomics and metabolomics could be beneficial for identifying key… read more here.
Keywords: style diet; western style; colitis; susceptibility ... See more keywords