Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes
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DOI: 10.1007/s11010-018-3429-2
Abstract: The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2D3), was reported to improve vascular function in patients with diabetes, yet the underlying mechanisms remain to be fully elucidated. Monoamine oxidase (MAO), a mitochondrial enzyme, with two… read more here.
Keywords: vascular function; monoamine oxidase; expression; experimental diabetes ... See more keywords
Endothelial Mineralocorticoid Receptor Ablation Confers Protection Towards Endothelial Dysfunction in Experimental Diabetes in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta physiologica"
DOI: 10.1111/apha.13731
Abstract: AIM With diabetes comes significant risk of macrovascular and microvascular complications. Circulating aldosterone levels increase in patients with diabetes. Aldosterone can directly affect vascular function via activation of the mineralocorticoid receptor (MR). We hypothesized that… read more here.
Keywords: aldosterone; mineralocorticoid receptor; mice; experimental diabetes ... See more keywords
Experimental diabetes exacerbates autophagic flux impairment during myocardial I/R injury through calpain‐mediated cleavage of Atg5/LAMP2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17642
Abstract: To explore the role of autophagic flux in the increased susceptibility of the experimental diabetic heart to ischaemia‐reperfusion (I/R) injury, we established STZ‐induced diabetic mice and performed I/R. In vitro, neonatal mouse cardiomyocytes were subjected… read more here.
Keywords: atg5 lamp2; autophagic flux; experimental diabetes; flux impairment ... See more keywords
81 Development of adverse cardiac remodelling in experimental diabetes is regulated by endothelial NOX4 nadph oxidase
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DOI: 10.1136/heartjnl-2018-bcs.81
Abstract: Background The characteristic structural and functional cardiac abnormalities which occur in diabetes, including fibrosis, inflammation and microvascular remodelling, and result in increased susceptibility to cardiovascular stress are largely mediated by reactive oxygen species (ROS) generation.… read more here.
Keywords: adverse cardiac; endothelial nox4; cardiac remodelling; nox4 nadph ... See more keywords
Tauopathy and cognitive impairment in experimental diabetes mellitus
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DOI: 10.14341/2072-0351-5842
Abstract: Currently, diabetes mellitus (DM) is the most common metabolic disorder, which is manifested by hyperglycemia and leads to vascular and cognitive impairment. Mechanisms of cognitive dysfunction in patients with DM remain highly unclear, thus complicating… read more here.
Keywords: tauopathy cognitive; mellitus tauopathy; cognitive impairment; diabetes mellitus ... See more keywords
Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.814165
Abstract: Contrasting evidence is present regarding the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes. Interestingly, a cell compartment with stem/progenitor cell features has been identified in the pancreatic duct glands (PDGs). The aims… read more here.
Keywords: regeneration; stz; duct glands; experimental diabetes ... See more keywords