Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model
Sign Up to like & getrecommendations! Published in 2017 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-017-3678-x
Abstract: PurposeClinical glaucoma is difficult to assess in terms of molecular pathophysiology, prompting studies in experimental models of glaucoma. The purpose of this study was to investigate quantitative changes in retinal protein expression at the onset… read more here.
Keywords: protein; intraocular pressure; experimental glaucoma; glaucoma ... See more keywords
Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108815
Abstract: Glaucoma is a neurodegenerative disease that affects eye structures and brain areas related to the visual system. Oxidative stress plays a key role in the development and progression of the disease. The aims of the… read more here.
Keywords: mitochondrial function; experimental glaucoma; glaucoma model; glaucoma ... See more keywords
Age and intraocular pressure in murine experimental glaucoma
Sign Up to like & getrecommendations! Published in 2021 at "Progress in retinal and eye research"
DOI: 10.1016/j.preteyeres.2021.101021
Abstract: Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. While IOP is commonly considered in models of experimental glaucoma (EG), most studies use juvenile… read more here.
Keywords: age intraocular; intraocular pressure; age; experimental glaucoma ... See more keywords
In situ-crosslinked hydrogel-induced experimental glaucoma model with persistent ocular hypertension and neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00552b
Abstract: A reliable animal model providing chronic and persistent ocular hypertension and characteristic neurodegeneration is essential to recapitulate human glaucoma and understand the underlying pathophysiological mechanisms behind this disease. Many approaches have been tried to establish… read more here.
Keywords: glaucoma; hydrogel; experimental glaucoma; model ... See more keywords
Neuroprotective Effects of Transferrin in Experimental Glaucoma Models
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112753
Abstract: Iron is essential for retinal metabolism, but an excess of ferrous iron causes oxidative stress. In glaucomatous eyes, retinal ganglion cell (RGC) death has been associated with dysregulation of iron homeostasis. Transferrin (TF) is an… read more here.
Keywords: glaucoma; neuroprotective effects; iron; effects transferrin ... See more keywords