In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection
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DOI: 10.1136/thoraxjnl-2021-217389
Abstract: Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction… read more here.
Keywords: bronchial epithelial; epithelial interferon; experimental rhinovirus; interferon ... See more keywords
Effect of CRTH2 antagonism on the response to experimental rhinovirus infection in asthma: a pilot randomised controlled trial
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DOI: 10.1136/thoraxjnl-2021-217429
Abstract: Background and aims The chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) antagonist timapiprant improved lung function and asthma control in a phase 2 study, with evidence suggesting reduced exacerbations. We aimed… read more here.
Keywords: experimental rhinovirus; timapiprant; infection; rhinovirus infection ... See more keywords