Explicit underdose control based on toxicity: Four points to consider
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DOI: 10.1002/sim.9492
Abstract: There are many design options for toxicity-driven phase 1 dose-finding in oncology drug development. There are methods that are simple, traditional and transparent, such as the 3 + 3 1 or rolling 6 design 2… read more here.
Keywords: explicit underdose; underdose control; control based; toxicity ... See more keywords