Exploitable metabolic dependencies in MLL-ENL-induced leukemia.
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DOI: 10.1182/bloodadvances.2020001710
Abstract: Mixed-lineage leukemia (MLL) fusions are transcriptional activators that induce leukemia, with a dismal prognosis that mandates further elucidation of their transformation mechanism. In this study, knockdown of the direct MLL-ENL target gene polypyrimidine tract binding… read more here.
Keywords: mll enl; ser; ser gly; exploitable metabolic ... See more keywords