Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design.
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DOI: 10.1016/j.ejmech.2021.113785
Abstract: HIV-1 reverse transcriptase (RT) plays a central role in the viral life cycle, and roughly half of the FDA-approved anti-HIV drugs are targeting RT. Nucleoside analogs (NRTIs) require cellular phosphorylation for binding to RT, and… read more here.
Keywords: reverse transcriptase; exploring dntp; hiv reverse;