Exploring the genetic heterogeneity in major depression across diagnostic criteria
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01231-w
Abstract: Major depressive disorder (MDD) is defined differently across genetic research studies and this may be a key source of heterogeneity. While previous literature highlights differences between minimal and strict phenotypes, the components contributing to this… read more here.
Keywords: depression; heterogeneity; major depression; depression phenotypes ... See more keywords
Exploring the Genetic Link Between Thyroid Dysfunction and Common Psychiatric Disorders: A Specific Hormonal or a General Autoimmune Comorbidity
Sign Up to like & getrecommendations! Published in 2022 at "Thyroid"
DOI: 10.1089/thy.2022.0304
Abstract: Background: The hypothalamus-pituitary-thyroid axis coordinates brain development and post-developmental function. Thyroid hormone variations, even within the normal range, have been associated with the risk of developing common psychiatric disorders, although the underlying mechanisms remain poorly… read more here.
Keywords: psychiatric disorders; thyroid; common psychiatric; exploring genetic ... See more keywords
Exploring genetic diversity in an Italian horse native breed to develop strategies for preservation and management
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Animal Breeding and Genetics"
DOI: 10.1111/jbg.12357
Abstract: Genetic diversity is a key factor for both adaptation and response to selection. The loss of genetic diversity causes a decrease in individual fitness, and it has a dramatically negative effect on population lifespan in… read more here.
Keywords: horse; diversity; genetic diversity; native breed ... See more keywords
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax4438
Abstract: Manifold destiny Mapping of genetic interactions (GIs) is usually based on cell fitness as the phenotypic readout, which obscures the mechanistic origin of interactions. Norman et al. developed a framework for mapping and understanding GIs.… read more here.
Keywords: single cell; cell rna; exploring genetic; genetic interactions ... See more keywords
Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001911
Abstract: Improvements to the production of proteins in industrial yeast species have largely relied on generating variation in a single genetic background. A new study in PLOS Biology leverages natural genetic variation to identify genes and… read more here.
Keywords: architecture protein; secretion komagataella; exploring genetic; genetic architecture ... See more keywords
Exploring the Genetic Variability and Potential Correlations Between Nutritional Quality and Agro-Physiological Traits in Kabuli Chickpea Germplasm Collection (Cicer arietinum L.)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.905320
Abstract: Chickpea is an important source of plant-based protein and mineral elements such as iron (Fe) and zinc (Zn). The development of superior high-yielding germplasm with high nutritional value becomes central for any breeding program. Chickpea… read more here.
Keywords: quality; exploring genetic; germplasm; correlation ... See more keywords