Exploring the Structural Space of the Galectin‐1–Ligand Interaction
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700251
Abstract: Galectin‐1 is a tumor‐associated protein recognizing the Galβ1‐4GlcNAc motif of cell‐surface glycoconjugates. Herein, we report the stepwise expansion of a multifunctional natural scaffold based on N‐acetyllactosamine (LacNAc). We obtained a LacNAc mimetic equipped with an… read more here.
Keywords: galectin ligand; exploring structural; galectin; structural space ... See more keywords
Exploring the Structural, Dielectric and Magnetic Properties of 5 Mol% Bi3+-Substituted CoCr2O4 Nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Superconductivity and Novel Magnetism"
DOI: 10.1007/s10948-019-05403-2
Abstract: In the present work for the first time, we report in-depth structural, electrical, optical and magnetic properties of a family of cobalt chromate nanoparticles with 5 mol% Bi3+ substitution of the average crystallite size of 15 nm,… read more here.
Keywords: exploring structural; structural dielectric; magnetic properties; mol bi3 ... See more keywords
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.073
Abstract: Guided by the crystal structure of 4-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)benzenesulfonamide 3 in complex with hCA II (PDB code 4Z0Q), a novel series of cycloalkylamino-1-carbonylbenzenesulfonamides was designed and synthesized. Thus, we replaced the quinoline ring with an azepine/piperidine/piperazine nucleus… read more here.
Keywords: exploring structural; structural properties; properties potent; potent human ... See more keywords
Exploring the Structural Diversity of DNA Bottlebrush Polymers Using an Oligonucleotide Macromonomer Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecules"
DOI: 10.1021/acs.macromol.1c02624
Abstract: Herein, we demonstrate that macromonomers consisting of organics-soluble, chemically protected oligonucleotides (protDNA) and poly(ethylene glycol) (PEG) chains can be converted into bottlebrush polymers of distinct architectures via ring-opening metathesis polymerization (ROMP). Using a custom norbornene-containing… read more here.
Keywords: diversity dna; exploring structural; peg; bottlebrush polymers ... See more keywords
Exploring the Structural Space of Chemiluminescent 1,2-Dioxetanes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c02371
Abstract: Chemiluminescent molecules which emit light in response to a chemical reaction are powerful tools for the detection and measurement of biological analytes and enable the understanding of complex biochemical processes in living systems. Triggerable chemiluminescent… read more here.
Keywords: space chemiluminescent; exploring structural; structural space; chemiluminescent dioxetanes ... See more keywords
Exploring structural complexity in the discovery and self-assembly of a family of nanoscale chalcoxides from {Se8Mo36} to {Se26Mo68}.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04398h
Abstract: Herein, we show the controlled generation of multi-component libraries based on the [MoS2O2]2+/MoVIO42-/SeIVO32-/C4O42- system leading to the formation of a whole new family of nanosized molecular chalcoxides, {Se8Mo36} 1, {Se8Mo40} 2, {Se8Mo56} 3, {Se20Mo56} 4… read more here.
Keywords: structural complexity; exploring structural; family; discovery ... See more keywords
Unequal by structure: Exploring the structural embeddedness of organizational diversity
Sign Up to like & getrecommendations! Published in 2018 at "Organization"
DOI: 10.1177/1350508417721337
Abstract: This article applies classical concepts of organizational structure and extends them to contemporary challenges of diversity to explore why unequal opportunity structures persist in an organization despite its commitment to diversity and employing highly skilled… read more here.
Keywords: exploring structural; diversity; unequal structure; structure exploring ... See more keywords
Exploring the Structural Rearrangements of the Human Insulin-Degrading Enzyme through Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031746
Abstract: Insulin-degrading enzyme (IDE) is a ubiquitously expressed metallopeptidase that degrades insulin and a large panel of amyloidogenic peptides. IDE is thought to be a potential therapeutic target for type-2 diabetes and neurodegenerative diseases, such as… read more here.
Keywords: dynamics simulations; molecular dynamics; exploring structural; insulin degrading ... See more keywords