Exploring Subsite Selectivity within Plasmodium vivaxN-Myristoyltransferase Using Pyrazole-Derived Inhibitors
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DOI: 10.1021/acs.jmedchem.4c00168
Abstract: N-myristoyltransferase (NMT) is a promising antimalarial drug target. Despite biochemical similarities between Plasmodium vivax and human NMTs, our recent research demonstrated that high selectivity is achievable. Herein, we report PvNMT-inhibiting compounds aimed at identifying novel… read more here.
Keywords: exploring subsite; subsite selectivity; selectivity within; myristoyltransferase ... See more keywords