Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.
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DOI: 10.1021/acsmedchemlett.8b00054
Abstract: Based on the detailed analysis of the binding mode of diarylpyrimidines (DAPYs) with HIV-1 RT, we designed several subseries of novel NNRTIs, with the aim to probe biologically relevant chemical space of solvent-exposed tolerant regions… read more here.
Keywords: ec50; binding pocket; exposed tolerant; hiv ... See more keywords