Voriconazole greatly increases the exposure to oral buprenorphine
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DOI: 10.1007/s00228-018-2548-8
Abstract: PurposeBuprenorphine has low oral bioavailability. Regardless of sublingual administration, a notable part of buprenorphine is exposed to extensive first-pass metabolism by the cytochrome P450 (CYP) 3A4. As drug interaction studies with buprenorphine are limited, we… read more here.
Keywords: exposure oral; voriconazole; increases exposure; buprenorphine ... See more keywords