Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24252
Abstract: The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activated by antibodies targeting the… read more here.
Keywords: trem2; receptor expressed; triggering receptor; myeloid cells ... See more keywords
Role of soluble triggering receptors expressed on myeloid cells‐1 and 25‐hydroxy vitamin D as early diagnostic markers of neonatal Ventilator‐associated pneumonia: A prospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26016
Abstract: Ventilator‐associated pneumonia (VAP) is one of the most common causes of nosocomial pneumonia in ventilated neonates. Nevertheless, its diagnosis is challenging due to the nonspecific clinical parameters and the lack of sensitive biomarkers. The main… read more here.
Keywords: soluble triggering; associated pneumonia; ventilator associated; receptors expressed ... See more keywords
A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study.
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2018.10.007
Abstract: AIMS No cohort study has examined the pathological significance of triggering receptor expressed on myeloid cell 2 (TREM2), a cell surface receptor expressed on myeloid lineage cells, and its soluble form, sTREM2, in insulin resistance… read more here.
Keywords: expressed myeloid; strem2; receptor expressed; insulin resistance ... See more keywords
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.09.034
Abstract: Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, contributes… read more here.
Keywords: expressed myeloid; histidine 157; myeloid cells; receptor expressed ... See more keywords
Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1486823
Abstract: ABSTRACT Introduction: There are currently no effective therapeutics for Alzheimer disease (AD). Clinical trials targeting amyloid beta thus far have shown very little benefit and only in the earliest stages of disease. These limitations have… read more here.
Keywords: expressed myeloid; alzheimer disease; myeloid cells; receptor expressed ... See more keywords
Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2017.1392855
Abstract: ABSTRACT Introduction: Periodontal diseases are polymicrobial inflammatory disorders of the tissue, ligament, and bone structures supporting teeth. Periodontitis (inflammation with corresponding loss of attachment) affects 40–50% of adults. Recently, members of the Triggering Receptor on… read more here.
Keywords: expressed myeloid; inflammation; receptor expressed; triggering receptor ... See more keywords
Triggering Receptor Expressed on Myeloid Cells 2, a Novel Regulator of Immunocyte Phenotypes, Confers Neuroprotection by Relieving Neuroinflammation
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001628
Abstract: Background: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. Methods: Mice were subjected to middle cerebral artery… read more here.
Keywords: expressed myeloid; immunocyte phenotypes; myeloid cells; receptor expressed ... See more keywords
The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000002167
Abstract: ABSTRACT Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane receptor on myeloid cells and plays an important role in the body's immune defense. Recently, TREM2 has received extensive attention from researchers, and… read more here.
Keywords: receptor expressed; cells apolipoprotein; triggering receptor; myeloid cells ... See more keywords
Role of triggering receptor expressed on myeloid cells 2 in neuroinflammation and neurodegeneration of the central nervous system
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.12479
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the TREM family of innate immune receptors. It is expressed on the cell membrane of myeloid lineage cells including osteoclasts and microglia. Since… read more here.
Keywords: expressed myeloid; myeloid cells; receptor expressed; role ... See more keywords
Abstract 3791: Triggering receptor expressed in myeloid cells 1 (TREM1) is a predictive marker for breast cancer therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-3791
Abstract: Triggering receptor expressed on myeloid cells-1 (TREM1) is a cell surface immunoglobulin that amplifies pro-inflammatory responses in myeloid cell populations and has been implicated in carcinogen-induced liver cancer. However, its role in breast cancer is… read more here.
Keywords: expressed myeloid; receptor expressed; breast cancer; cancer ... See more keywords
Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker.
Sign Up to like & getrecommendations! Published in 2021 at "Revista da Associacao Medica Brasileira"
DOI: 10.1590/1806-9282.20200765
Abstract: OBJECTIVE Triggering receptor expressed on myeloid cells-1 concentration can be used as a predictive, diagnostic, and prognostic marker in patients with sepsis. The objective of this study was to determine the validity of triggering receptor… read more here.
Keywords: sepsis; expressed myeloid; myeloid cells; receptor expressed ... See more keywords