Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02978-5
Abstract: AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired… read more here.
Keywords: dysfunctional phenotype; aml patients; expressing cells; increased tigit ... See more keywords
Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2018.10.007
Abstract: High-bone-mass (HBM)-causing missense mutations in the low density lipoprotein receptor-related protein-5 (Lrp5) are associated with increased osteoanabolic action and protection from disuse- and ovariectomy-induced osteopenia. These mutations (e.g., A214V and G171V) confer resistance to endogenous… read more here.
Keywords: hbm; lrp5 hbm; expressing cells; hbm causing ... See more keywords
Cdc42 in osterix-expressing cells alters osteoblast behavior and myeloid lineage commitment.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116150
Abstract: Osteoblasts are not only responsible for bone formation. They also support hematopoiesis. This requires responding to cues originating from several signaling pathways, a task performed by Rho GTPases. We therefore examined several transgenic mouse models… read more here.
Keywords: cdc42; expressing cells; bone; cells alters ... See more keywords
Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Reports"
DOI: 10.1016/j.celrep.2022.110377
Abstract: Summary The precise developmental dynamics of the pancreatic islet endocrine cell types, and their interrelation, are unknown. Some authors claim the persistence of islet cell differentiation from precursor cells after birth (“neogenesis”). Here, using four… read more here.
Keywords: hormone expressing; islet; expressing cells; cell ... See more keywords
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Reports"
DOI: 10.1016/j.celrep.2022.110503
Abstract: Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with… read more here.
Keywords: peptide; sars cov; abrogates inhibition; nkg2a expressing ... See more keywords
Non-canonical Eclosion Hormone-Expressing Cells Regulate Drosophila Ecdysis
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101108
Abstract: Summary Eclosion hormone (EH) was originally identified as a brain-derived hormone capable of inducing the behavioral sequences required for molting across insect species. However, its role in this process (called ecdysis) has since been confounded… read more here.
Keywords: ecdysis; hormone; expressing cells; eclosion hormone ... See more keywords
Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.05.009
Abstract: Fibroblast growth factors (FGF) are essential signaling proteins that regulate diverse cellular functions in developmental and metabolic processes. In Drosophila, the FGF homolog, branchless (bnl) is expressed in a dynamic and spatiotemporally restricted pattern to… read more here.
Keywords: expressing cells; morphogenesis; expression; bnl expressing ... See more keywords
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14060
Abstract: Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on… read more here.
Keywords: u2af1 expressing; mutant u2af1; expressing cells; u2af1 s34f ... See more keywords
Renin cells in homeostasis, regeneration and immune defence mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/nrneph.2017.186
Abstract: An accumulating body of evidence suggests that renin-expressing cells have developed throughout evolution as a mechanism to preserve blood pressure and fluid volume homeostasis as well as to counteract a number of homeostatic and immunological… read more here.
Keywords: defence; expressing cells; cells homeostasis; renin cells ... See more keywords
Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice
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DOI: 10.1038/s41598-021-95380-1
Abstract: Previously, genetic lineage tracing based on the mesothelial marker Wt1, appeared to show that peritoneal mesothelial cells have a range of differentiative capacities and are the direct progenitors of vascular smooth muscle in the intestine.… read more here.
Keywords: expressing cells; postnatal adult; wt1 expressing; adult mice ... See more keywords
E74 Like ETS Transcription Factor 3 is a Negative Regulator of Pathogenic Lamina Propria T Helper 17.1 Cells in Murine Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2084409
Abstract: ABSTRACT Interleukin-17A (IL-17A)-expressing T cells, including T helper 17 (Th17) and T helper 17.1 (Th17.1) cells, play a significant role in inflammatory bowel diseases (IBDs). Identifying the mechanisms underlying the heterogeneity and plasticity of IL-17A-expressing… read more here.
Keywords: th17 cells; elf3; expressing cells; th17 ... See more keywords