Bioactivation mechanisms of N‐hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22321
Abstract: Aristolochic acids (AAs) are human nephrotoxins and carcinogens found in concoctions of Aristolochia plants used in traditional medicinal practices worldwide. Genotoxicity of AAs is associated with the formation of active species catalyzed by metabolic enzymes,… read more here.
Keywords: strains expressing; aristolochic acids; expressing human; mechanisms hydroxyaristolactams ... See more keywords
Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154793
Abstract: Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic… read more here.
Keywords: expressing human; transgenic mice; insulin resistance; mice ... See more keywords
A novel microglia cell line expressing the human EP2 receptor.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00311
Abstract: Recently, EP2 signaling pathways were shown to regulate the classical activation and death of microglia in rat primary microglial culture. The study of microglial cells has been challenging because they are time consuming to isolate… read more here.
Keywords: bv2 hep2; ep2; cell line; microglia ... See more keywords
Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1211774
Abstract: Abstract 1. Cell models expressing human drug transporters and enzymes are useful tools to understand the process of drug disposition in vitro. However, no study on transfected cells stably co-expressing human organic anion transporter 1 (hOAT1)… read more here.
Keywords: hoat1 hcyp1a2; expressing human; cell models; hoat1 ... See more keywords
Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006348
Abstract: Background Tumor necrosis factor superfamily member 14 (TNFRSF14)/herpes virus entry mediator (HVEM) is the ligand for B and T lymphocyte attenuator (BTLA) and CD160-negative immune co-signaling molecules as well as viral proteins. Its expression is… read more here.
Keywords: mouse; btla; expressing human; hvem ... See more keywords
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006214
Abstract: Key Points We generated novel hemophilia A or B mice expressing human protein C. Selectively blocking the anticoagulant activity of human activated protein C improves the clotting defects in hemophilia mice. read more here.
Keywords: human protein; mice expressing; expressing human; anticoagulant activity ... See more keywords