Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110023
Abstract: SUMMARY The global impact of somatic structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized. Here, using whole-genome and RNA sequencing from 570 recurrent or metastatic tumors,… read more here.
Keywords: mediated cis; rearrangement mediated; regulatory alterations; expression associations ... See more keywords
JEBIN: analyzing gene co-expressions across multiple datasets by joint network embedding
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab603
Abstract: The inference of gene co-expression associations is one of the fundamental tasks for large-scale transcriptomic data analysis. Due to the high dimensionality and high noises in transcriptomic data, it is difficult to infer stable gene… read more here.
Keywords: cell; gene expressions; expression associations; expression ... See more keywords