NeTFactor, a framework for identifying transcriptional regulators of gene expression-based biomarkers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49498-y
Abstract: Biological and regulatory mechanisms underlying many multi-gene expression-based disease biomarkers are often not readily evident. We describe an innovative framework, NeTFactor, that combines network analyses with gene expression data to identify transcription factors (TFs) that… read more here.
Keywords: expression based; biomarker; netfactor; gene expression ... See more keywords
A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1558664
Abstract: ABSTRACT This study aimed to establish the number of expression-based molecular subclasses in cutaneous melanoma, identify their dominant biological pathways and evaluate their clinical relevance. To this end, consensus clustering was performed separately on two… read more here.
Keywords: expression; molecular subclasses; cutaneous melanoma; based molecular ... See more keywords
Gene expressionâbased drug repurposing to target aging
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12819
Abstract: Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism studies have shown that genetic and chemical perturbations can extend both lifespan and healthspan. Aging is a complex process, with parallel… read more here.
Keywords: expression based; drug repurposing; expression; gene expression ... See more keywords
Comprehensive analysis of mutation and expression based pathways in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e18015
Abstract: e18015Background: Over- or under expression of mRNA result from genetic alteration. mRNA expression based pathway are as important as single gene level mutations analyzed by next generation sequenc... read more here.
Keywords: expression based; comprehensive analysis; mutation expression; expression ... See more keywords
Prognostic Gene Expression-Based Signature in Clear-Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153754
Abstract: Simple Summary In this study, we identified molecular markers for disease progression from ccRCC tissue samples. Using the selected biomarkers and clinical data from the TCGA cohort, we developed a gene expression-based signature which enhances… read more here.
Keywords: cell; expression based; signature; expression ... See more keywords
A Novel Two-Gene Expression-Based Prognostic Score in Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13091556
Abstract: Background: Malignant pleural mesothelioma (MPM) is a rare cancer type with an increasing incidence worldwide. We aimed to develop a rational gene expression-based prognostic score in MPM using publicly available datasets. Methods: We developed and… read more here.
Keywords: expression based; based prognostic; gene expression; score ... See more keywords
Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012707
Abstract: The purpose of this study was to evaluate the association between four distinct histopathological features: (1) tumor infiltrating lymphocytes, (2) mucinous differentiation, (3) tumor-stroma ratio, plus (4) tumor budding and two gene expression-based classifiersâ(1) consensus… read more here.
Keywords: expression based; histopathological features; based classifiers; gene expression ... See more keywords