The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22431
Abstract: Pneumoconiosis is a serious occupational disease worldwide, which is characterized by irreversible and diffuse lung fibrotic lesions. Laminin beta 1(LAMB1) is widely expressed in tissues and it is crucial for both lung morphogenesis and physiological… read more here.
Keywords: lamb1 polymorphism; lamb1; expression changes; association lamb1 ... See more keywords
Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0772-3
Abstract: We aimed to identify blood gene expression patterns associated to psychopathological trajectories retrieved from a large community, focusing on the emergence and remission of general psychiatric symptoms. Hundred and three individuals from the Brazilian High-Risk… read more here.
Keywords: expression changes; cohort; psychopathology; gene expression ... See more keywords
Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28280-1
Abstract: Identifying the molecular systems and proteins that modify the progression of Alzheimer’s disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic… read more here.
Keywords: using deep; expression; deep neural; protein expression ... See more keywords
Cytotoxic, genotoxic, and toxicogenomic effects of dihydroxyacetone in human primary keratinocytes
Sign Up to like & getrecommendations! Published in 2021 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2021.1931877
Abstract: Abstract Purpose Dihydroxyacetone (DHA) is the only ingredient approved by the U.S. FDA as a colour additive in sunless tanning (self-tanning) products. Consumer sunless tanning products available for retail purchase contain 1–15% DHA. Although originally… read more here.
Keywords: primary keratinocytes; gene expression; expression changes; dha ... See more keywords
Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum
Sign Up to like & getrecommendations! Published in 2019 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2019.1595142
Abstract: ABSTRACT Both deletions and duplications of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, encoding excitatory postsynaptic scaffolds, are causally associated with various brain disorders, suggesting that proper Shank3 dosage is critical for… read more here.
Keywords: dosage; expression changes; gene expression; shank3 dosage ... See more keywords
Novel diabetes gene discovery through comprehensive characterization and integrative analysis of longitudinal gene expression changes
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac039
Abstract: Abstract Type 2 diabetes is a complex, systemic disease affected by both genetic and environmental factors. Previous research has identified genetic variants associated with type 2 diabetes risk; however, gene regulatory changes underlying progression to… read more here.
Keywords: gene; type diabetes; gene expression; expression changes ... See more keywords
α and β catalytic subunits of cAMP‐dependent protein kinase regulate formoterol‐induced inflammatory gene expression changes in human bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15901
Abstract: It has been proposed that genomic mechanisms contribute to adverse effects often experienced by asthmatic subjects who take regular, inhaled β2‐adrenoceptor agonists as a monotherapy. Moreover, data from preclinical models of asthma suggest that these… read more here.
Keywords: bronchial epithelial; expression changes; gene expression; epithelial cells ... See more keywords
Prenatal androgenization causes expression changes of progesterone and androgen receptor mRNAs in the arcuate nucleus of female mice across development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroendocrinology"
DOI: 10.1111/jne.13058
Abstract: Prenatal exposure to excess androgens is associated with the development of polycystic ovary syndrome (PCOS). In prenatally androgenised (PNA) mice, a model of PCOS, progesterone receptor (PR) protein expression is reduced in arcuate nucleus (ARC)… read more here.
Keywords: treatment; expression changes; expression; mice ... See more keywords
Rapid, broad‐scale gene expression evolution in experimentally harvested fish populations
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Ecology"
DOI: 10.1111/mec.14179
Abstract: Gene expression changes potentially play an important role in adaptive evolution under human‐induced selection pressures, but this has been challenging to demonstrate in natural populations. Fishing exhibits strong selection pressure against large body size, thus… read more here.
Keywords: expression changes; gene; gene expression; evolution experimentally ... See more keywords
Genome‐scale signatures of adaptive gene expression changes in an invasive seaweed Gracilaria vermiculophylla
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16776
Abstract: Invasive species can successfully and rapidly colonize new niches and expand ranges via founder effects and enhanced tolerance towards environmental stresses. However, the underpinning molecular mechanisms (i.e., gene expression changes) facilitating rapid adaptation to harsh… read more here.
Keywords: seaweed gracilaria; expression; gracilaria vermiculophylla; gene expression ... See more keywords
Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
Sign Up to like & getrecommendations! Published in 2019 at "mSphere"
DOI: 10.1128/msphere.00575-18
Abstract: The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions.… read more here.
Keywords: population; gene expression; cell; expression changes ... See more keywords