Disruption of a −35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells
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DOI: 10.1158/1078-0432.ccr-17-3678
Abstract: Purpose: MLH1 is a major tumor suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of regulating MLH1 expression over long distances have… read more here.
Keywords: colorectal cells; mlh1 expression; expression; ctcf ... See more keywords
Expression of PD-L1 in colorectal cancer that lack mutations in RAS or TP53 genes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14500
Abstract: e14500Background: PD-L1 expression as detected by immunohistochemistry (IHC) is significantly lower in colorectal cancers (CRC) when compared with lung cancer or other types of cancer. We explored if mutations in the RAS/RAF gene family, TP53… read more here.
Keywords: mutations ras; expression; cancer; expression colorectal ... See more keywords
Prognostic value of PD-L1 expression in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.610
Abstract: 610Background: Growing evidence have shown promise for targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling in several tumors. However, the role of PD-L1 expression in colorectal cancer (CRC) tumor cells and its interaction with other… read more here.
Keywords: prognostic value; colorectal cancer; expression; cancer ... See more keywords
Clinicopathological analysis of PD-L2 expression in colorectal cancer
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DOI: 10.2147/ott.s177329
Abstract: Background (PD-L2), a ligand of programmed cell death protein 1 (PD-1), is an inhibitory receptor of T cells and activated B cells. Many studies have focused on PD-L1, another ligand of PD-1, and the prognostic… read more here.
Keywords: clinicopathological analysis; colorectal cancer; expression; analysis expression ... See more keywords