Reduced expression of DNA repair genes and chemosensitivity in 1p19q codeleted lower-grade gliomas
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2915-4
Abstract: BackgroundLower-grade gliomas (LGGs, defined as WHO grades II and III) with 1p19q codeletion have increased chemosensitivity when compared to LGGs without 1p19q codeletion, but the mechanism is currently unknown.MethodsRNAseq data from 515 LGG patients in… read more here.
Keywords: repair genes; expression dna; dna repair;
Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation
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DOI: 10.1080/21623945.2020.1732513
Abstract: ABSTRACT Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired glucose regulation (IGR), the results were compared to bariatric surgery, considering it an intensive… read more here.
Keywords: intervention; expression dna; lifestyle intervention; dna ... See more keywords
Identifying Stages of Kidney Renal Cell Carcinoma by Combining Gene Expression and DNA Methylation Data
Sign Up to like & getrecommendations! Published in 2017 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2016.2607717
Abstract: In this study, in order to take advantage of complementary information from different types of data for better disease status diagnosis, we combined gene expression with DNA methylation data and generated a fused network, based… read more here.
Keywords: expression dna; network; network based; gene expression ... See more keywords
Genotoxic Effects of Lead and Their Impact on the Expression of DNA Repair Genes
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DOI: 10.3390/ijerph19074307
Abstract: Exposure to lead (Pb) continues to be a significant worldwide problem. Pb is a highly poisonous heavy metal affecting several organ systems in the body. Although Pb has been shown to be genotoxic to experimental… read more here.
Keywords: expression dna; dna repair; repair genes; dna ... See more keywords
Gene Expression and DNA Methylation in Human Papillomavirus Positive and Negative Head and Neck Squamous Cell Carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810967
Abstract: High-risk human papillomaviruses (HPV) are important agents, responsible for a large percentage of the 745,000 cases of head and neck squamous cell carcinomas (HNSCC), which were identified worldwide in 2020. In addition to being virally… read more here.
Keywords: expression dna; methylation; gene expression; expression ... See more keywords
The Anticancer Drug Daunomycin Directly Affects Gene Expression and DNA Structure
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076631
Abstract: Daunomycin (DM), an anthracycline antibiotic, is frequently used to treat various cancers, but the direct effects of DM on gene expression and DNA structure are unclear. We used an in vitro cell-free system, optimized with… read more here.
Keywords: expression dna; gene; gene expression; structure ... See more keywords
Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation
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DOI: 10.3892/ol.2018.8574
Abstract: The present study assessed the expression of the DNA doublestrand repair (DDR) proteins ATM serine/threonine kinase (ATM), checkpoint kinase 2 (CHEK2) and γH2A histone family member X (γH2AFX) in oral leukoplakia (OL) and evaluated their… read more here.
Keywords: risk; expression dna; doublestrand repair; dna doublestrand ... See more keywords
Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.83115
Abstract: Understanding what factors influence plastic and genetic variation is valuable for predicting how organisms respond to changes in the selective environment. Here, using gene expression and DNA methylation as molecular phenotypes, we study environment-induced variation… read more here.
Keywords: expression dna; dna methylation; gene expression; expression ... See more keywords