α2A- and α2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.05.012
Abstract: Previous evidence suggests that α2-adrenoceptors (α2-AR) may be involved in the pathophysiology of schizophrenia. However, postmortem brain studies on α2-AR expression and functionality in schizophrenia are scarce. The aim of our work was to evaluate… read more here.
Keywords: schizophrenia; expression functionality; antipsychotic free; schizophrenia subjects ... See more keywords
TNF-α and IL-1β Exposure Modulates the Expression and Functionality of P-Glycoprotein in Intestinal and Renal Barriers.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00140
Abstract: Inflammation is characterized by an increased secretion of proinflammatory cytokines known to alter the expression and functionality of drug transporters. Since P-glycoprotein (P-gp) plays a key role in the pharmacokinetics of several drugs, these modulations… read more here.
Keywords: expression functionality; drug; exposure; intestinal renal ... See more keywords