Fine‐tuning Nanog expression heterogeneity in embryonic stem cells by regulating a Nanog transcript‐specific microRNA
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13936
Abstract: In embryonic stem cells (ESCs), the transcription factor Nanog maintains the stemness of ESCs despite exhibiting heterogeneous expression patterns under varied culture conditions. Efficient fine‐tuning of Nanog expression heterogeneity could enable ESC proliferation and differentiation… read more here.
Keywords: stem cells; expression; embryonic stem; expression heterogeneity ... See more keywords
Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity
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DOI: 10.1182/blood-2018-99-119075
Abstract: Background. Acute Myeloid Leukemia (AML) is genetically and epigenetically heterogeneous. Most AML samples display clonal heterogeneity at presentation, which evolves with therapeutic interventions. To better understand the epigenetic consequences of clonal heterogeneity, we are using… read more here.
Keywords: single cell; heterogeneity; expression; expression heterogeneity ... See more keywords