Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00410-x
Abstract: Enteroviruses (EVs) 3C proteins suppress type I interferon (IFN) responses mediated by retinoid acid-inducible gene I (RIG-I), while an E3 ubiquitin ligase, tripartite motif protein 25 (TRIM25)-mediated RIG-I ubiquitination is essential for RIG-I antiviral activity.… read more here.
Keywords: rig expression; expression; expression ifn; trim25 ... See more keywords
Pelareorep to promote the expression of a IFN-gamma-related gene signature that predicts response to checkpoint blockade therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3089
Abstract: 3089Background: A clinical study in patients (pts) with metastatic breast cancer (mBC) treated with pelareorep resulted in significant improvements in overall survival. Clinical studies with checkp... read more here.
Keywords: gamma related; expression ifn; promote expression; pelareorep promote ... See more keywords
Impact and prognosis of the expression of IFN-α among tuberculosis patients
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DOI: 10.1371/journal.pone.0235488
Abstract: Mycobacterium tuberculosis (M.tb) infection stimulates the release of cytokines, including interferons (IFNs). IFNs are initiators, regulators, and effectors of innate and adaptive immunity. Accordingly, the expression levels of Type I (α, β) and II (γ)… read more here.
Keywords: expression ifn; ifn; tuberculosis patients; expression ... See more keywords