Towards a Universal Characterization of the Membrane Protein Expression Landscape
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1046
Abstract: Integral membrane proteins (IMPs) are critical players in cellular homeostasis and as such represent over 60% of all drug targets. However, their complex biochemical makeup means that integration into membrane bilayers and heterologous overexpression in… read more here.
Keywords: expression landscape; expression; membrane; sequence ... See more keywords
The microdissected gene expression landscape of nasopharyngeal cancer reveals vulnerabilities in FGF and noncanonical NF-κB signaling
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abh2445
Abstract: Nasopharyngeal cancer (NPC) is an Epstein-Barr virus (EBV)–positive epithelial malignancy with an extensive inflammatory infiltrate. Traditional RNA-sequencing techniques uncovered only microenvironment signatures, while the gene expression of the tumor epithelial compartment has remained a mystery.… read more here.
Keywords: gene; nasopharyngeal cancer; gene expression; expression landscape ... See more keywords
PD-L1 expression landscape and its relationship with tumor mutation burden in Chinese cancer patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15267
Abstract: e15267Background: Little is known about the pan-cancer PD-L1 expression landscape in Chinese patients although PD-L1 expression has been approved by FDA as a diagnosis for anti-PD-(L)1 therapy in s... read more here.
Keywords: expression landscape; landscape relationship; tumor mutation; cancer ... See more keywords
Protein Expression Landscape Defines the Formation Potential of Mouse Blastoids From EPSCs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.840492
Abstract: Preimplantation embryo development is a precisely regulated process organized by maternally inherited and newly synthesized proteins. Recently, some studies have reported that blastocyst-like structures, named blastoids, can be generated from mouse ESCs (embryonic stem cells)… read more here.
Keywords: protein expression; mouse; expression; eps blastoids ... See more keywords