Natural swietenine attenuates diabetic nephropathy by regulating the NF‐κB/NLRP3/Caspase‐1 signaling pathways: In vivo and in vitro study
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23653
Abstract: Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates inflammation and oxidative stress, and diabetic nephropathy has a close connection with them. So the effects of Swi on diabetic nephropathy and its mechanism of action was… read more here.
Keywords: nlrp3 caspase; diabetic nephropathy; expression nlrp3;
Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.06.014
Abstract: BACKGROUND Neonatal inflammation may affect brain development and lead to cognitive and emotional deficits at adolescence and adulthood. The nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is the core component of… read more here.
Keywords: expression nlrp3; early life; like behavior; adolescent rats ... See more keywords
PKR induces the expression of NLRP3 by regulating the NF‐&kgr;B pathway in Porphyromonas gingivalis‐infected osteoblasts
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DOI: 10.1016/j.yexcr.2017.03.028
Abstract: ABSTRACT The double‐stranded RNA‐dependent kinase (PKR), which is activated by double stranded RNA, induces inflammation by regulating NF‐&kgr;B signaling. The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome also modulates inflammation in response to infection. Porphyromonas… read more here.
Keywords: expression nlrp3; inflammation; gingivalis; expression ... See more keywords
Characterization of Cathepsin B in Mediating Silica Nanoparticle-Induced Macrophage Pyroptosis via an NLRP3-Dependent Manner
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DOI: 10.2147/jir.s371536
Abstract: Introduction Silica nanoparticles (SiNPs) are one of the most widely used inorganic nanomaterials, and exposure to SiNP has been demonstrated to induce pulmonary inflammation, primarily promoted by the NLRP3-mediated macrophage pyroptosis. However, mechanisms underlying the… read more here.
Keywords: macrophage pyroptosis; ctsb; expression nlrp3; pyroptosis ... See more keywords
PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.649572
Abstract: NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted… read more here.
Keywords: irf8 modulate; expression nlrp3; modulate activation; expression ... See more keywords