Predicting Gene Expression Noise from Gene Expression Variations.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7710-9_13
Abstract: The level of gene expression is known to vary from cell to cell and even in the same cell over time. This variability provides cells with the ability to mitigate environmental stresses and genetic perturbations,… read more here.
Keywords: gene expression; expression variations; expression noise; gene ... See more keywords
Stress-Induced Constraint on Expression Noise of Essential Genes in E. coli
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-024-10211-x
Abstract: Gene expression is an inherently noisy process that is constrained by natural selection. Yet the condition dependence of constraint on expression noise remains unclear. Here, we address this problem by studying constraint on expression noise… read more here.
Keywords: expression; essential genes; constraint expression; expression noise ... See more keywords
Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109573
Abstract: MicroRNAs (miRNAs) have been shown to modulate gene expression noise, but less is known about how miRNAs with different properties may regulate noise differently. Here, we investigate the role of competing RNAs and the composition… read more here.
Keywords: gene expression; noise; expression noise; gene ... See more keywords
Deconvolution of Gene Expression Noise into Spatial Dynamics of Transcription Factor-Promoter Interplay.
Sign Up to like & getrecommendations! Published in 2017 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.6b00397
Abstract: Gene expression noise is not only the mere consequence of stochasticity, but also a signal that reflects the upstream physical dynamics of the cognate molecular machinery. Soil bacteria facing recalcitrant pollutants exploit noise of catabolic… read more here.
Keywords: expression noise; expression; gene expression; promoter ... See more keywords
Promoter shape varies across populations and affects promoter evolution and expression noise
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3791
Abstract: Animal promoters initiate transcription either at precise positions (narrow promoters) or dispersed regions (broad promoters), a distinction referred to as promoter shape. Although highly conserved, the functional properties of promoters with different shapes and the… read more here.
Keywords: evolution; promoter shape; shape; promoter ... See more keywords
Orthogonal tuning of gene expression noise using CRISPR–Cas
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa451
Abstract: Abstract The control of gene expression noise is important for improving drug treatment and the performance of synthetic biological systems. Previous work has tuned gene expression noise by changing the rate of transcription initiation, mRNA… read more here.
Keywords: expression noise; gene; orthogonal tuning; gene expression ... See more keywords
Extrinsic noise prevents the independent tuning of gene expression noise and protein mean abundance in bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc3478
Abstract: Gene expression noise cannot be tuned independently of protein mean abundance for most bacterial genes. It is generally accepted that prokaryotes can tune gene expression noise independently of protein mean abundance by varying the relative… read more here.
Keywords: transcription; abundance; noise; mean abundance ... See more keywords
Genome-Wide Analysis of Gene Expression Noise Brought About by Transcriptional Regulation in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00963-22
Abstract: The phenotypic diversity of Pseudomonas aeruginosa is frequently observed in research, suggesting that bacteria adopt strategies such as bet-hedging to survive ever-changing environments. Gene expression noise (GEN) is the major source of phenotypic diversity. ABSTRACT… read more here.
Keywords: pseudomonas aeruginosa; diversity; transcriptional regulation; regulation ... See more keywords