Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33547
Abstract: Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as expression quantitative trait… read more here.
Keywords: quantitative trait; multiple myeloma; survival multiple; expression ... See more keywords
Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0026-9_11
Abstract: Expression quantitative trait loci (eQTL) mapping studies identify genetic loci that regulate gene expression. eQTL mapping studies can capture gene regulatory interactions and provide insight into the genetic mechanism of biological systems. Recently, the integration… read more here.
Keywords: loci; multi omics; omics data; eqtl ... See more keywords
Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.01.065
Abstract: Multiple single nucleotide polymorphisms (SNPs) have been found to be highly correlated with colorectal cancer (CRC) risk. However, the variants identified thus far only explain a small part of the cases, suggesting the existence of… read more here.
Keywords: analysis; colorectal cancer; quantitative trait; expression ... See more keywords
Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07692-y
Abstract: Clinical studies of non-communicable diseases identify multimorbidities that suggest a common set of predisposing factors. Despite the fact that humans have ~24,000 genes, we do not understand the genetic pathways that contribute to the development… read more here.
Keywords: target genes; quantitative trait; expression quantitative; trait loci ... See more keywords
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants
Sign Up to like & getrecommendations! Published in 2020 at "Nature Genetics"
DOI: 10.1038/s41588-020-00745-3
Abstract: Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis -regulatory elements… read more here.
Keywords: expression; quantitative trait; expression quantitative; trait loci ... See more keywords
Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98348-3
Abstract: ETS variant transcription factor 4 (ETV4) is a recently identified transcription factor that regulates gene expression-based biomarkers of asthma and IL6 production in an airway epithelial cell line. Given that ETV4 has not yet been… read more here.
Keywords: expression quantitative; etv4; adult asthma; associated adult ... See more keywords
Methods and Insights from Single-Cell Expression Quantitative Trait Loci.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-101422-100437
Abstract: Recent advancements in single-cell technologies have enabled expression quantitative trait locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk RNA sequencing, which averages gene expression across cell types and cell states, single-cell… read more here.
Keywords: cell; cell states; expression quantitative; quantitative trait ... See more keywords
Tumor expression quantitative trait methylation screening reveals distinct CpG panels for deconvolving cancer immune signatures.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3113
Abstract: DNA methylation signatures in tumors could serve as reliable biomarkers that are accessible in archival tissues for tracking the epigenetic dynamics shaped by both cancer cells and the tumor microenvironment. However, given the ultra-high-dimensionality and… read more here.
Keywords: methylation; expression quantitative; quantitative trait; trait methylation ... See more keywords
Systems genomics study reveals expression quantitative trait loci, regulator genes and pathways associated with boar taint in pigs
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192673
Abstract: Boar taint is an offensive odour and/or taste from a proportion of non-castrated male pigs caused by skatole and androstenone accumulation during sexual maturity. Castration is widely used to avoid boar taint but is currently… read more here.
Keywords: trait loci; quantitative trait; boar taint; eqtls ... See more keywords
Using expression quantitative trait loci data and graph-embedded neural networks to uncover genotype–phenotype interactions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.921775
Abstract: Motivation: A central goal of current biology is to establish a complete functional link between the genotype and phenotype, known as the so-called genotype–phenotype map. With the continuous development of high-throughput technology and the decline… read more here.
Keywords: multi omics; expression quantitative; graph embedded; graph ... See more keywords
Refined expression quantitative trait locus analysis on adenocarcinoma at the gastroesophageal junction reveals susceptibility and prognostic markers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1180500
Abstract: Objectives: This study aimed to explore cell type level expression quantitative trait loci (eQTL) in adenocarcinoma at the gastroesophageal junction (ACGEJ) and identify susceptibility and prognosis markers. Methods: Whole-genome sequencing (WGS) was performed on 120… read more here.
Keywords: adenocarcinoma gastroesophageal; expression quantitative; gastroesophageal junction; quantitative trait ... See more keywords