Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12506
Abstract: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are… read more here.
Keywords: sarcolemmal dystrophin; expression required; pathology; expression ... See more keywords
What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-019-09535-9
Abstract: Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disease. The disease is due to mutations in the DMD gene that encodes for a large intracellular protein called dystrophin. Dystrophin plays a critical role… read more here.
Keywords: effective therapy; muscle; muscular dystrophy; expression required ... See more keywords
LH signaling induced ptgs2a expression is required for ovulation in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.02.042
Abstract: It is well known that ovulation is induced by luteinizing hormone (LH) surge. However, the down-stream factors that mediating LH surge induced ovulation are less clear. The cyclooxygenases (also known as PTGS) as key enzymes… read more here.
Keywords: ptgs2a expression; signaling induced; expression required; expression ... See more keywords