A three‐lncRNA expression signature associated with the prognosis of gastric cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1047
Abstract: Long noncoding RNAs (lncRNAs) have emerged as essential players in gene regulation. An ever‐increasing number of lncRNAs has been found to be associated with the biogenesis and prognosis of gastric cancer (GC). We aimed to… read more here.
Keywords: lncrna expression; prognosis; expression signature; expression ... See more keywords
Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24220
Abstract: Prostate cancer (PCa) is a genetically heterogeneous disease with highly molecular aberrations. It has been revealed that a newly discovered class of non‐coding RNAs called circular RNAs (circRNAs) play key roles in dictating tumor behaviors… read more here.
Keywords: prostate cancer; values expression; prostate; clinical values ... See more keywords
A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18546-x
Abstract: Identifying factors underlying resistance to immune checkpoint therapy (ICT) is still challenging. Most cancer patients do not respond to ICT and the availability of the predictive biomarkers is limited. Here, we re-analyze a publicly available… read more here.
Keywords: signature trem2hi; response; expression signature; gene expression ... See more keywords
Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx358
Abstract: Hereditary hemorrhagic telangiectasia (HHT) is a highly debilitating and life-threatening genetic vascular disorder arising from endothelial cell (EC) proliferation and hypervascularization, for which no cure exists. Because HHT is caused by loss-of-function mutations in bone… read more here.
Keywords: expression signature; gene expression; pathology; loss function ... See more keywords
Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression.
Sign Up to like & getrecommendations! Published in 2023 at "Bipolar disorders"
DOI: 10.1111/bdi.13319
Abstract: OBJECTIVES The aim of this study was to repurpose a drug for the treatment of bipolar depression. METHODS A gene expression signature representing the overall transcriptomic effects of a cocktail of drugs widely prescribed to… read more here.
Keywords: treat bipolar; bipolar depression; trimetazidine; depression ... See more keywords
MicroRNA Expression Signature in Human Calcific Aortic Valve Disease
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/4820275
Abstract: Altered microRNA (miRNA, miR) expression has been related to many disease processes; however, the miRNA expression signature in calcific aortic valve disease (CAVD) is unclear. In this study, microarrays were used to determine the miRNA… read more here.
Keywords: expression signature; disease; expression; calcific aortic ... See more keywords
Evaluation of the Stellae-123 prognostic gene expression signature in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.968340
Abstract: Risk stratification in acute myeloid leukemia (AML) has been extensively improved thanks to the incorporation of recurrent cytogenomic alterations into risk stratification guidelines. However, mortality rates among fit patients assigned to low or intermediate risk… read more here.
Keywords: signature; expression signature; stellae 123; gene expression ... See more keywords