Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures
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DOI: 10.1016/j.nbd.2020.105244
Abstract: There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in… read more here.
Keywords: sig1r; expression subunit; susceptibility seizures; decreased expression ... See more keywords