The Curative Effects of Vitamins D3&K2 on the Expressions of p53, Bax, Bcl-2, and Oxidative Stress Induced by Methotrexate in ZFL Epithelial Cells
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DOI: 10.1089/jmf.2024.0261
Abstract: Methotrexate (MTX), a folate antimetabolite, is a cytotoxic drug known to cause cytotoxicity associated with free oxygen radicals. This study investigated the effect of vitamins D3 and K2 on MTX-induced liver cell injury using the… read more here.
Keywords: methotrexate; liver cell; expressions p53; bax bcl ... See more keywords
Expressions of p53 and PUMA in fibroblasts of systemic sclerosis patients are normal at transcription level
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DOI: 10.1111/jocd.12420
Abstract: Systemic sclerosis (SSc) fibroblasts show resistance apoptosis mechanisms, which enhances the fibrosis stage of the disease. Impaired function of p53 upregulated modulator of apoptosis (PUMA) has been related to deficits in p53‐dependant apoptosis pathway. This… read more here.
Keywords: puma fibroblasts; expressions p53; p53 puma; fibroblasts systemic ... See more keywords