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Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000836
Abstract: Quantitative assessment of hepatic clearance (CLH) of drugs is critical to accurately predict human dose and drug-drug interaction (DDI) liabilities. This is challenging for drugs that involve complex transporter-enzyme interplay. In this study, we demonstrate…
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Keywords:
clearance;
pevonedistat;
clearance model;
ddi ... See more keywords