The β8 integrin EGF domains support a constitutive extended conformation, and the cytoplasmic domain impairs outside‐in signaling
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DOI: 10.1002/jcp.30871
Abstract: Integrins are transmembrane proteins that transmit bi‐directional signals across the cell membrane through global structural rearrangement among three different conformational states: bent, extended‐ closed, and extended‐open conformations. However, the β8 integrin is distinctive and may… read more here.
Keywords: conformation; ligand binding; outside signaling; extended conformation ... See more keywords
An extended conformation of SARS-CoV-2 main protease reveals allosteric targets
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120913119
Abstract: Significance The coronavirus main protease (Mpro) is required for viral replication. Here, we obtained the extended conformation of the native monomer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro by trapping it with nanobodies… read more here.
Keywords: conformation; allosteric targets; main protease; extended conformation ... See more keywords