Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25747
Abstract: Vaginal rings are a promising approach to provide a woman‐centred, long‐acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of… read more here.
Keywords: vaginal rings; phase pharmacokinetics; safety; pharmacokinetics safety ... See more keywords
Is Extended-Duration (Post-Hospital Discharge) Venous Thromboembolism Chemoprophylaxis Safe and Efficacious in High-Risk Surgery Patients? A Systematic Review
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DOI: 10.1007/s00268-020-05638-4
Abstract: The risk of venous thromboembolism (VTE) persists beyond hospitalization in surgical patients, yet post-hospital discharge chemoprophylaxis regimens are not common. The purpose of this study is to systematically review the literature regarding extended-duration (post-hospital discharge)… read more here.
Keywords: risk; high risk; post hospital; chemoprophylaxis ... See more keywords
Extended Duration Running and Impulse Loading Characteristics of an Acoustic Bearing with Enhanced Geometry
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DOI: 10.1007/s11249-017-0831-y
Abstract: This paper presents performance during prolonged running of the acoustic bearing when PZTs are switched off and when they are switched on. The effect of active PZT on shaft’s displacements in X and Y directions… read more here.
Keywords: acoustic bearing; duration running; geometry; impulse force ... See more keywords
The safety and efficacy of full‐ versus reduced‐dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended‐Duration Betrixaban (APEX) trial
Sign Up to like & getrecommendations! Published in 2017 at "American Heart Journal"
DOI: 10.1016/j.ahj.2016.12.004
Abstract: Background The APEX trial assessed the safety and efficacy of extended‐duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80‐mg betrixaban dose was halved to 40 mg among… read more here.
Keywords: safety; extended duration; apex trial; efficacy ... See more keywords
Effect of extended‐duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13783
Abstract: Essentials Anticoagulants prevent venous thromboembolism but may be associated with greater bleeding risks. Bivariate analysis assumes a non‐linear relationship between efficacy and safety outcomes. Extended full‐dose betrixaban is favorable over standard enoxaparin in bivariate endpoint.… read more here.
Keywords: venous thromboembolism; extended duration; bivariate analysis; effect extended ... See more keywords
Extended-duration letermovir prophylaxis for cytomegalovirus infection after cord blood transplantation in adults
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022008047
Abstract: Key Points • Letermovir is a highly effective and well-tolerated CMV prophylaxis in adult CBT recipients.• Extended CMV prophylaxis for at least 6 months is beneficial in adult CBT recipients, but optimal prophylaxis duration remains… read more here.
Keywords: extended duration; letermovir prophylaxis; duration letermovir; prophylaxis ... See more keywords
Acceptability of an extended duration vaginal ring for HIV prevention and interest in a multi-purpose ring
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263664
Abstract: Given challenges with adherence to existing HIV prevention products, the development of an extended duration vaginal ring could improve adherence while reducing patient and provider burden. Additionally, women have other interlinked sexual health concerns such… read more here.
Keywords: extended duration; vaginal ring; duration; hiv prevention ... See more keywords