Effect of Colonic Absorption on the Pharmacokinetic Properties of Delayed‐Release and Extended‐Release Methylphenidate: In Vivo, In Vitro, and Modeling Evaluations
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DOI: 10.1002/cpdd.1089
Abstract: Most stimulants used to treat attention‐deficit/hyperactivity disorder are administered in the morning and absorbed in the upper gastrointestinal tract. DR/ER‐MPH (formerly HLD200), an evening‐dosed delayed‐release and extended‐release methylphenidate, is predicted to be absorbed in the… read more here.
Keywords: formulation; release; release methylphenidate; extended release ... See more keywords
Model‐Informed Development and Registration of a Once‐Daily Regimen of Extended‐Release Tofacitinib
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DOI: 10.1002/cpt.576
Abstract: Extended‐release (XR) formulations enable less frequent dosing vs. conventional (e.g., immediate release (IR)) formulations. Regulatory registration of such formulations typically requires pharmacokinetic (PK) and clinical efficacy data. Here we illustrate a model‐informed, exposure–response (E‐R) approach… read more here.
Keywords: tofacitinib; extended release; model informed; registration ... See more keywords
Use of Causal Framework to Evaluate Effect of Abuse Deterrent Properties of Extended‐Release Oxycodone on Tampering in a Real‐World Settings
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DOI: 10.1002/pds.70085
Abstract: To assess whether exposure to an extended‐release (ER) oxycodone with abuse deterrent properties (ADF) reduced tampering of oxycodone in a real‐world, postmarket setting to address the thinking behind Category 4 labeling by the FDA. read more here.
Keywords: oxycodone; deterrent properties; abuse deterrent; extended release ... See more keywords
Extended release versus immediate release tacrolimus in kidney transplant recipients: a systematic review and meta-analysis
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DOI: 10.1007/s00228-018-2512-7
Abstract: PurposeTo compare the estimated glomerular filtration rate (eGFR) at 12 months together with other outcomes among adult kidney transplant recipients (KTRs) who received extended release, once daily tacrolimus (ER-Tac) compared to those who received the immediate… read more here.
Keywords: extended release; immediate release; kidney transplant; transplant recipients ... See more keywords
Plasma Lipidome Analysis by Liquid Chromatography-High Resolution Mass Spectrometry and Ion Mobility of Hypertriglyceridemic Patients on Extended-Release Nicotinic Acid: a Pilot Study
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DOI: 10.1007/s10557-017-6737-y
Abstract: BackgroundPlasma high triacylglycerols and low HDL-C concentration are associated with increased cardiovascular events. Extended-release nicotinic acid (ERN) was shown to reduce plasma triacylglycerols and total cholesterol but also to markedly increase high-density lipoprotein-cholesterol (HDL-C). No… read more here.
Keywords: extended release; spectrometry; mass spectrometry; analysis ... See more keywords
Exploring the use of extended release opioids at shortened dosing intervals in people with chronic pain and high risk medication or substance use
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-020-01027-y
Abstract: Background Critical attention to rational opioid prescribing has emerged from the opioid epidemic in North America. Individuals with chronic pain are prescribed extended release opioids in an effort to maintain stable drug levels and for… read more here.
Keywords: use; extended release; release opioids; chronic pain ... See more keywords
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
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DOI: 10.1007/s13346-024-01598-7
Abstract: In this technical note we show with two simple experiments how Perfluorodecalin (PFD), an injectable perfluorocarbon, can be used as an agent for resuspending microparticulate suspensions in primary packaging containers for injection. Furthermore, we explain… read more here.
Keywords: sediment solidification; extended release; resuspension; primary packaging ... See more keywords
Onapristone Extended Release: Safety Evaluation from Phase I–II Studies with an Emphasis on Hepatotoxicity
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DOI: 10.1007/s40264-020-00964-x
Abstract: Introduction Antiprogestins have demonstrated promising activity against breast and gynecological cancers, but liver-related safety concerns limited the advancement of this therapeutic class. Onapristone is a full progesterone receptor antagonist originally developed as an oral contraceptive… read more here.
Keywords: phase studies; safety; onapristone; extended release ... See more keywords
An approach to natural insect repellent formulations: from basic research to technological development.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105419
Abstract: The incidence of dengue, Zika, chikungunya, yellow fever and malaria cases has increased significantly in the world. To avoid mosquito bites, one of the best strategies is the use of repellents. The interest in using… read more here.
Keywords: research; extended release; repellent activity; repellent formulations ... See more keywords
Role of hydroxypropylmethylcellulose (HPMC 4000) in the protection of the polymorphs of Piroxicam extended release tablets
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.03.005
Abstract: Abstract The present study deals with the influence of hydroxypropylmethylcellulose 4000 in the protection of Piroxicam polymorphs which could appear during the processes of formulation of extended release tablets. The physico-chemical tests and the dissolution… read more here.
Keywords: extended release; piroxicam; release tablets; 4000 protection ... See more keywords
A Randomized Phase I Study to Assess the Effect of Alcohol on the Pharmacokinetics of an Extended-release Orally Disintegrating Tablet Formulation of Amphetamine in Healthy Adults.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.07.006
Abstract: PURPOSE There is a strong association between attention-deficit/hyperactivity disorder (ADHD) and alcohol abuse, yet no studies have systematically assessed the effect of alcohol on the pharmacokinetics of psychostimulants such as amphetamine (AMP) in vivo. This… read more here.
Keywords: amp; extended release; study; effect alcohol ... See more keywords