N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09815-4
Abstract: N-Acetylcysteine (NAc) has been shown to play a diversity of favorable health-related roles (e.g., antioxidant, paracetamol antidote, mucolytics, neuroprotective agent). Having said that, here in this study, we evaluate the health-promoting properties of NAc, particularly… read more here.
Keywords: drosophila; extends lifespan; via modulating; acetylcysteine extends ... See more keywords
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.05.015
Abstract: Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD+ availability plays a critical role in regulating the aging process across many species. Here, we show that… read more here.
Keywords: extracellular vesicle; contained enampt; extends lifespan; enampt delays ... See more keywords
Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.104341
Abstract: Abstract Neoagarotetraose (NAT) has been reported to ameliorate aging-associated diseases. The present study found that NAT extended the lifespan of Caenorhabditis (C.) elegans up to 21.9% and improved resistance to stresses of heat and oxidation.… read more here.
Keywords: elegans ampk; extends lifespan; caenorhabditis elegans; neoagarotetraose extends ... See more keywords
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.
Sign Up to like & getrecommendations! Published in 2022 at "Aging cell"
DOI: 10.1111/acel.13604
Abstract: Methionine restriction (MetR) can extend lifespan and delay the onset of aging-associated pathologies in most model organisms. Previously, we showed that supplementation with the metabolite S-adenosyl-L-homocysteine (SAH) extends lifespan and activates the energy sensor AMP-activated… read more here.
Keywords: lifespan methionine; adenosyl homocysteine; extends lifespan; homocysteine extends ... See more keywords
Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/4740739
Abstract: Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis… read more here.
Keywords: elegans via; medicine; extends lifespan; via insulin ... See more keywords
Hypoxia extends lifespan and neurological function in a mouse model of aging
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002117
Abstract: There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence in cultured cells and extends lifespan in yeast, nematodes, and fruit flies. Here, we asked… read more here.
Keywords: chronic continuous; hypoxia; model aging; extends lifespan ... See more keywords
Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Marine drugs"
DOI: 10.3390/md20010059
Abstract: Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove Sonneratia apetala, showed remarkable… read more here.
Keywords: sonneradon extends; sda; caenorhabditis elegans; lifespan caenorhabditis ... See more keywords
PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.26952
Abstract: The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan. We show that similar developmental stress is necessary… read more here.
Keywords: extends lifespan; developmental mitochondrial; mitochondrial stress; stress ... See more keywords