Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26543
Abstract: Monoclonal antibodies (mAbs) currently dominate the biopharmaceutical sector due to their potency and efficacy against a range of disease targets. These proteinaceous therapeutics are, however, susceptible to unfolding, mis‐folding, and aggregation by environmental perturbations. Aggregation… read more here.
Keywords: aggregation; flow reveal; extensional flow; reveal diverse ... See more keywords
Deformation of a biconcave-discoid capsule in extensional flow and electric field
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluid Mechanics"
DOI: 10.1017/jfm.2018.879
Abstract: Natural (red blood cells) and artificial biconcave-discoid-shaped capsules have immense biological (a cellular component of blood) and technological (as drug carrier) relevance, respectively. Their low reduced volume allows significant shape changes under external fields such… read more here.
Keywords: electric fields; transition; shape; extensional flow ... See more keywords
Microstructural Dynamics and Rheology of Worm-like Diblock Copolymer Nanoparticle Dispersions under a Simple Shear and a Planar Extensional Flow
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecules"
DOI: 10.1021/acs.macromol.2c01314
Abstract: We investigate the shear and extensional flow behavior of dispersions composed of two types of worm-like nanoparticles (WLNPs) with comparable cross-sectional diameters, similar persistence lengths but differing contour lengths, and thus differing flexibility. By measuring… read more here.
Keywords: wlnp; planar extensional; rheology; flow ... See more keywords
Electrically modulated relaxation dynamics of pre-stretched droplets post switched-off uniaxial extensional flow.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01813b
Abstract: Droplets are known to elongate in extensional flow and exhibit capillary instabilities following flow cessation. Under several practical scenarios, where the deformed drops are exposed to electrified environments, the interplay between capillary and electric forces… read more here.
Keywords: electric field; extensional flow; relaxation; relaxation dynamics ... See more keywords
Extensional-Flow Impedance Cytometer for Contactless and Optics-Free Erythrocyte Deformability Analysis
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2022.3197214
Abstract: Objective: Deformability is an essential feature of red blood cells (RBCs), enabling them to undergo significant shape change in response to external forces. Impaired erythrocyte deformability is associated with several pathologic conditions, and quantitative measurement… read more here.
Keywords: erythrocyte deformability; optics free; optics; contactless optics ... See more keywords
Capillary breakup extensional electrorheometry (CaBEER)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Rheology"
DOI: 10.1122/1.5116718
Abstract: A new electrorheological cell for the capillary breakup extensional rheometer (HaakeTM CaBER 1TM, Thermo Scientific) allowing the analysis of the rheological properties of complex fluids under the simultaneous application of an extensional flow and an… read more here.
Keywords: breakup extensional; field; extensional flow; capillary breakup ... See more keywords
Recoverable Extensional Flow of Polymer Melts and Its Relevance for Processing
Sign Up to like & getrecommendations! Published in 2020 at "Polymers"
DOI: 10.3390/polym12071512
Abstract: While the uniaxial elongational viscosity is widely investigated, and its relevance for processing is described in the literature, much less has been published on the recoverable extensional flow of polymer melts. This paper presents a… read more here.
Keywords: relevance processing; flow polymer; polymer; extensional flow ... See more keywords