Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.5c00102
Abstract: Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that recruit E3 ubiquitin ligases to a target protein and induce its ubiquitination by forming a ternary complex. However, the structural dynamics underlying the complex formation and degradation… read more here.
Keywords: distribution; extensive conformational; conformational search; ternary complex ... See more keywords
Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215371120
Abstract: Significance Despite being identified as the strongest genetic risk factor for Alzheimer’s disease more than 20 years ago, a connection between the biochemical properties of apolipoprotein E (ApoE) and its role in the disease remains… read more here.
Keywords: lipid bound; apolipoprotein extensive; lipid; extensive conformational ... See more keywords