Involuntary mental rotation and visuospatial imagery from external control
Sign Up to like & getrecommendations! Published in 2019 at "Consciousness and Cognition"
DOI: 10.1016/j.concog.2019.102809
Abstract: The Reflexive Imagery Task (RIT) was developed to investigate the entry into consciousness of involuntary imagery. Subjects are presented with objects and instructed to not think of the names of the objects. Involuntary subvocalizations arise… read more here.
Keywords: visuospatial imagery; mental rotation; rotation visuospatial; external control ... See more keywords
Optical bistability via an external control field in all-fiber ring cavity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09570-x
Abstract: We demonstrate a new scheme for realizing the Optical Bistability (OB) inside an all-fiber ring cavity with an external control field. In the absence of the external control field, the pump power is fixed below… read more here.
Keywords: control; external control; cavity; control field ... See more keywords
Exploring the Potential of External Control Arms created from Patient Level Data: A case study in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2021.2011901
Abstract: ABSTRACT Randomized controlled trials (RCTs) are the gold standard for evaluation of new medical products. However, RCTs may not always be ethical or feasible. In cases where the investigational product is available outside the trial… read more here.
Keywords: case study; external control; control arms; control ... See more keywords
Abstract PD4-08: An FDA analysis of survival outcomes comparing adjuvant paclitaxel and trastuzumab trial (APT) to an external control from historical clinical trials
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-pd4-08
Abstract: Background: The Adjuvant Paclitaxel and Trastuzumab (APT) trial was a single-arm trial in patients with small node-negative HER2-positive early breast cancer (EBC). Although the regimen used in the APT trial has been adopted clinically, single-arm… read more here.
Keywords: paclitaxel trastuzumab; trial; patients treated; external control ... See more keywords
Approaches to Selecting “Time Zero” in External Control Arms with Multiple Potential Entry Points: A Simulation Study of 8 Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Medical Decision Making"
DOI: 10.1177/0272989x221096070
Abstract: Background When including data from an external control arm to estimate comparative effectiveness, there is a methodological choice of when to set “time zero,” the point at which a patient would be eligible/enrolled in a… read more here.
Keywords: external control; time; time zero; simulation ... See more keywords
Pertuzumab Plus Trastuzumab for Treatment-Refractory HER2-Amplified Metastatic Colorectal Cancer: Comparison of the MyPathway Trial With a Real-World External Control Arm
Sign Up to like & getrecommendations! Published in 2022 at "JCO Clinical Cancer Informatics"
DOI: 10.1200/cci.22.00022
Abstract: PURPOSE We compared overall survival (OS) in patients with human epidermal growth factor receptor 2 (HER2)–amplified, treatment-refractory metastatic colorectal cancer (mCRC) receiving pertuzumab plus trastuzumab (PER-HER) in the phase IIa MyPathway multibasket study (ClinicalTrials.gov identifier:… read more here.
Keywords: external control; her2 amplified; arm; treatment refractory ... See more keywords
Application of Real-World Data to External Control Groups in Oncology Clinical Trial Drug Development
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.695936
Abstract: Randomized controlled trials (RCTs) that assess overall survival are considered the “gold standard” when evaluating the efficacy and safety of a new oncology intervention. However, single-arm trials that use surrogate endpoints (e.g., objective response rate… read more here.
Keywords: external control; drug; world data; real world ... See more keywords
A multi-center effectiveness comparison study of fruquintinib with constructed external control cohort of other targeted kinase inhibitors using real-world data in third-line treatment of metastatic colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1044328
Abstract: Objective The objective of this study was to assess the comparative efficacy in third-line setting for metastatic CRC (mCRC) patients using matched population of FRESCO trial with fruquintinib and real-world data with other TKIs. Materials… read more here.
Keywords: external control; study; third line; world data ... See more keywords