External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients
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DOI: 10.1007/s00228-020-02922-z
Abstract: Beta-lactams (BL), the most commonly prescribed class of antibiotics, are recommended as the first-line therapy for multiple indications in infectious disease guidelines. Meropenem (MERO) is frequently used in intensive care units (ICU) to treat bacterial… read more here.
Keywords: pharmacokinetic models; population pharmacokinetic; external evaluation; evaluation ... See more keywords
Implementation of the IHR Joint External Evaluation: Taiwan's Experiences
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DOI: 10.1089/hs.2016.0093
Abstract: In February 2016, the World Health Organization developed the Joint External Evaluation (JEE) tool to independently assess country capacity to prevent, detect, and respond to public health threats as part of the International Health Regulations… read more here.
Keywords: implementation ihr; external evaluation; evaluation; joint external ... See more keywords
The Joint External Evaluation of Taiwan: The External Evaluators' Perspective
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DOI: 10.1089/hs.2016.0109
Abstract: A team of experts from the Johns Hopkins Center for Health Security conducted an independent external assessment of Taiwan's capabilities under the International Health Regulations 2005 (IHR), using the IHR Joint External Evaluation (JEE) tool… read more here.
Keywords: health security; external evaluation; joint external; taiwan ... See more keywords
US CENTERS FOR DISEASE CONTROL AND PREVENTION EXPERIENCE IN THE JOINT EXTERNAL EVALUATION PROCESS—RADIATION EMERGENCIES TECHNICAL AREA
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DOI: 10.1093/rpd/ncy148
Abstract: In 2015-16, the US Department of Health and Human Services led 23 US Government (USG) agencies including the Centers for Disease Control and Prevention (CDC), and more than 120 subject matter experts in conducting an… read more here.
Keywords: disease control; radiation emergencies; centers disease; external evaluation ... See more keywords
External evaluation of population pharmacokinetics and pharmacodynamics in linezolid-induced thrombocytopenia: the transferability of published models to different hospitalized patients.
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DOI: 10.1097/ftd.0000000000000816
Abstract: OBJECTIVES The objective of the present study was to perform an external evaluation of published linezolid population pharmacokinetic and pharmacodynamic models, in order to evaluate the predictive performance using an independent dataset. Another aim was… read more here.
Keywords: pharmacokinetic pharmacodynamic; external evaluation; population; population pharmacokinetic ... See more keywords
Towards Precision Dosing of Clozapine in Schizophrenia: External Evaluation of Population Pharmacokinetic Models and Bayesian Forecasting
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DOI: 10.1097/ftd.0000000000000987
Abstract: Supplemental Digital Content is Available in the Text. Background: Therapeutic drug monitoring and treatment optimization of clozapine are recommended, owing to its narrow therapeutic range and pharmacokinetic (PK) variability. This study aims to assess the… read more here.
Keywords: predictive performance; external evaluation; bayesian forecasting; model ... See more keywords
External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models
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DOI: 10.1128/aac.01352-17
Abstract: ABSTRACT Fluconazole is an antifungal agent used for the treatment of invasive candidiasis, a leading cause of morbidity and mortality in premature infants. Population pharmacokinetic (PK) models of fluconazole in infants have been previously published… read more here.
Keywords: population pharmacokinetic; external evaluation; model; population ... See more keywords
Is countries’ transparency associated with gaps between countries’ self and external evaluations for IHR core capacity?
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DOI: 10.1186/s12992-020-0541-3
Abstract: Background This study aims to evaluate the gap between countries’ self-evaluation and external evaluation regarding core capacity of infectious disease control required by International Health Regulations and the influence factors of the gap. Methods We collected… read more here.
Keywords: status; gap; capacity; countries self ... See more keywords
External Evaluation of Population Pharmacokinetic Models of Busulfan in Chinese Adult Hematopoietic Stem Cell Transplantation Recipients
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DOI: 10.3389/fphar.2022.835037
Abstract: Objective: Busulfan (BU) is a bi-functional DNA-alkylating agent used in patients undergoing hematopoietic stem cell transplantation (HSCT). Over the last decades, several population pharmacokinetic (pop PK) models of BU have been established, but external evaluation… read more here.
Keywords: external evaluation; based diagnostics; prediction; hematopoietic stem ... See more keywords
External Evaluation of Population Pharmacokinetic Models to Inform Precision Dosing of Meropenem in Critically Ill Patients
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DOI: 10.3389/fphar.2022.838205
Abstract: Routine clinical meropenem therapeutic drug monitoring data can be applied to model-informed precision dosing. The current study aimed to evaluate the adequacy and predictive capabilities of the published models with routine meropenem data and identify… read more here.
Keywords: precision dosing; meropenem concentrations; external evaluation; meropenem ... See more keywords