Brain activation during fear extinction predicts exposure success
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DOI: 10.1002/da.22583
Abstract: Exposure therapy, a gold‐standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC)… read more here.
Keywords: activation fear; extinction; extinction learning; brain activation ... See more keywords
High vagal tone and rapid extinction learning as potential transdiagnostic protective factors following childhood violence exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental psychobiology"
DOI: 10.1002/dev.22176
Abstract: Childhood exposure to violence is strongly associated with psychopathology. High resting respiratory sinus arrhythmia (RSA) is associated with lower levels of psychopathology in children exposed to violence. High RSA may help to protect against psychopathology… read more here.
Keywords: violence; extinction learning; psychopathology; exposure ... See more keywords
Individual differences in extinction learning predict weight loss after treatment: A pilot study
Sign Up to like & getrecommendations! Published in 2020 at "European Eating Disorders Review"
DOI: 10.1002/erv.2778
Abstract: Abstract Learning theorists suggest extinction learning to be a central mechanism in weight loss success; however, empirical studies are scarce. In this pilot study, it was examined whether individual differences in extinction learning predict outcome… read more here.
Keywords: individual differences; treatment; extinction; weight loss ... See more keywords
Administration of riluzole to the basolateral amygdala facilitates fear extinction in rats
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.08.031
Abstract: A general understanding exists that inhibition of glutamatergic neurotransmission in the basolateral amygdala (BLA) impairs fear extinction in rodents. Surprisingly, we recently found that systemic administration of riluzole, which has been shown to inhibit the… read more here.
Keywords: administration; extinction; administration riluzole; basolateral amygdala ... See more keywords
NMDA receptors in the avian amygdala and the premotor arcopallium mediate distinct aspects of appetitive extinction learning
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.01.026
Abstract: HIGHLIGHTSWe investigate extinction learning with pigeons under appetitive conditions.We block NMDARs in the amygdala or the (pre)motor arcopallium during extinction.Blocking NMDARs in the amygdala impairs extinction acquisition.Blocking arcopallial NMDARs impairs consolidation of extinction memory.We show… read more here.
Keywords: consolidation; extinction; extinction learning; arcopallium ... See more keywords
Continuous exposure to α-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.02.024
Abstract: Abstract This study investigated the effect of exogenously administered polyphenolic antioxidant, α-glycosyl isoquercitrin (AGIQ), on neural function in rats following dietary exposure at 0.5% from gestational day 6 to postnatal day 77, in comparison with… read more here.
Keywords: fear extinction; agiq; extinction learning; glycosyl isoquercitrin ... See more keywords
A ventral striatal prediction error signal in human fear extinction learning
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DOI: 10.1016/j.neuroimage.2020.117709
Abstract: Animal studies have shown that the prediction error (PE) signal that drives fear extinction learning is encoded by phasic activity of midbrain dopamine (DA) neurons. Thus, the extinction PE resembles the appetitive PE that drives… read more here.
Keywords: prediction error; extinction; error signal; extinction learning ... See more keywords
Fear extinction learning modulates large-scale brain connectivity
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118261
Abstract: Exploring the neural circuits of the extinction of conditioned fear is critical to advance our understanding of fear-and anxiety-related disorders. The field has focused on examining the role of various regions of the medial prefrontal… read more here.
Keywords: connectivity; extinction; extinction learning; fear extinction ... See more keywords
The cerebellum contributes to context-effects during fear extinction learning: A 7T fMRI study
Sign Up to like & getrecommendations! Published in 2022 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2022.119080
Abstract: The cerebellum is involved in the acquisition and consolidation of learned fear responses. Knowledge about its contribution to extinction learning, however, is sparse. Extinction processes likely involve erasure of memories, but there is ample evidence… read more here.
Keywords: cerebellum; extinction learning; memory; extinction training ... See more keywords
d-Cycloserine facilitates extinction learning and enhances extinction-related brain activation
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.08.003
Abstract: Extinction learning is modulated by N-methyl d-aspartate receptors (NMDAR) particularly in prefrontal and hippocampal brain regions. The use of of NMDA agonists in exposure therapy of anxiety disorders has been investigated in various patient groups.… read more here.
Keywords: context; extinction; cycloserine; extinction learning ... See more keywords
The DA-antagonist Tiapride affects context-related extinction learning in a predictive learning task, but not initial forming of associations, or renewal
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2021.107465
Abstract: Renewal describes the recovery of an extinguished response if the contexts of extinction and recall differ, highlighting the context dependency of extinction. Studies demonstrated dopaminergic (DA) signalling to be important for context-related extinction learning with… read more here.
Keywords: context related; renewal; extinction; extinction learning ... See more keywords