Sodium formate redirects carbon flux and enhances heterologous mevalonate production in Methylobacterium extorquens AM1
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200402
Abstract: Methylobacterium extorquens AM1 (AM1), a model strain of methylotrophic cell factories (MeCFs) could be used to produce fine chemicals from methanol. Synthesis of heterologous products usually needs reducing cofactors, but AM1 growing on methanol lack… read more here.
Keywords: methylobacterium extorquens; formate; extorquens am1; sodium formate ... See more keywords
Structural insight into a molecular mechanism of methenyltetrahydrofolate cyclohydrolase from Methylobacterium extorquens AM1.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.072
Abstract: Bioconversion of the C1 compounds into value-added products is one of the CO2-reducing strategies. In particular, because CO2 can be easily converted into formate, the efficient and direct bioconversion of CO2 through formate assimilation is… read more here.
Keywords: formate assimilation; extorquens am1; molecular mechanism; methylobacterium extorquens ... See more keywords
Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2016.11.010
Abstract: Acetyl-CoA is not only an important intermediate metabolite for cells but also a significant precursor for production of industrially interesting metabolites. Methylobacterium extorquens AM1, a model strain of methylotrophic cell factories using methanol as carbon… read more here.
Keywords: mevalonate; transcriptional regulator; coa; extorquens am1 ... See more keywords
An engineered Calvin-Benson-Bassham cycle for carbon dioxide fixation in Methylobacterium extorquens AM1.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2018.04.003
Abstract: Organisms are either heterotrophic or autotrophic, meaning that they cover their carbon requirements by assimilating organic compounds or by fixing inorganic carbon dioxide (CO2). The conversion of a heterotrophic organism into an autotrophic one by… read more here.
Keywords: cycle; extorquens am1; cbb cycle; carbon dioxide ... See more keywords
Development of Methylorubrum extorquens AM1 as a promising platform strain for enhanced violacein production from co-utilization of methanol and acetate.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2022.03.008
Abstract: Violacein, a blue-violet compound with a wide range of beneficial bioactivities, is an attractive product for microbial production. Currently, violacein production has been demonstrated in several sugar heterotrophs through metabolic engineering; however, the cost of… read more here.
Keywords: development; extorquens am1; production; violacein production ... See more keywords
Gene products and processes contributing to lanthanide homeostasis and methanol metabolism in Methylorubrum extorquens AM1
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69401-4
Abstract: Lanthanide elements have been recently recognized as “new life metals” yet much remains unknown regarding lanthanide acquisition and homeostasis. In Methylorubrum extorquens AM1, the periplasmic lanthanide-dependent methanol dehydrogenase XoxF1 produces formaldehyde, which is lethal if… read more here.
Keywords: homeostasis; microscopy; methylorubrum extorquens; gene products ... See more keywords
Hyperaccumulation of Gadolinium by Methylorubrum extorquens AM1 Reveals Impacts of Lanthanides on Cellular Processes Beyond Methylotrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.820327
Abstract: Lanthanides (Ln) are a new group of life metals, and many questions remain regarding how they are acquired and used in biology. Methylotrophic bacteria can acquire, transport, biomineralize, and use Ln as part of a… read more here.
Keywords: hyperaccumulation gadolinium; extorquens am1; gadolinium; hyperaccumulation ... See more keywords
Five copper homeostasis gene clusters encode the Cu-efflux resistome of the highly copper-tolerant Methylorubrum extorquens AM1
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.14925
Abstract: Background In the last decade, the use of copper has reemerged as a potential strategy to limit healthcare-associated infections and to control the spread of multidrug-resistant pathogens. Numerous environmental studies have proposed that most opportunistic… read more here.
Keywords: copper tolerance; extorquens am1; copper; methylorubrum extorquens ... See more keywords