Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
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DOI: 10.1016/j.bioorg.2020.103767
Abstract: Bis-hydrazides 13a-h were designed and synthesized as potential tubulin inhibitors selectively targeting the colchicine site between α- and β-tubulin subunits. The newly designed ring-B substituents were assisted at their ends by 'anchor groups' which are… read more here.
Keywords: tubulin inhibitors; tubulin; extra binding; colchicine site ... See more keywords