Abstract 3965: KIFC1 is a therapeutic target in lung cancers with extra centrosomes
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3965
Abstract: Introduction: Lung cancer is a deadly malignancy and new treatments targeting mechanisms promoting its growth and progression are needed. Genomic instability (GIN) is a recurrent feature of lung tumours that promotes drug resistance and other… read more here.
Keywords: kifc1; extra centrosomes; luad; lung ... See more keywords
Keep Calm and Carry on with Extra Centrosomes
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DOI: 10.3390/cancers14020442
Abstract: Simple Summary Precise chromosome segregation during mitosis is a vital event orchestrated by formation of bipolar spindle poles. Supernumerary centrosomes, caused by centrosome amplification, deteriorates mitotic processes, resulting in segregation defects leading to chromosomal instability… read more here.
Keywords: keep calm; extra centrosomes; calm carry; centrosome amplification ... See more keywords
Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells
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DOI: 10.7554/elife.54565
Abstract: Tetraploidy has long been of interest to both cell and cancer biologists, partly because of its documented role in tumorigenesis. A common model proposes that the extra centrosomes that are typically acquired during tetraploidization are… read more here.
Keywords: asymmetric clustering; centrosomes defines; extra centrosomes; tetraploid ... See more keywords