Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.006
Abstract: Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia.… read more here.
Keywords: regulatory element; element binding; sterol regulatory; cancer ... See more keywords
Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63524-w
Abstract: The plasma membrane (PM), a physical barrier separating cells from their environment, responds to fluctuating extracellular environment through receptor-mediated signaling. While these pathways have been extensively studied, the role of PM lipids remains poorly understood.… read more here.
Keywords: cells adapt; extracellular acidic; acidic tm9sf3; pip2 translocation ... See more keywords