Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2959
Abstract: Glycolysis and fatty acid synthesis are highly active in cancer cells through cytosolic citrate metabolism, with intracellular citrate primarily derived from either glucose or glutamine via the tricarboxylic acid cycle. We show here that extracellular… read more here.
Keywords: citrate; cell metabolism; cancer cell; cancer ... See more keywords
Extracellular Citrate and Cancer Metabolism-Response.
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DOI: 10.1158/0008-5472.can-18-1899
Abstract: In response to our recent article showing that cancer cells take up extracellular citrate through the plasma membrane-specific variant (pmCiC) of the mitochondrial citrate transporter and that depriving cancer cells of extracellular citrate by blocking… read more here.
Keywords: response; citrate; citrate cancer; cancer metabolism ... See more keywords
Extracellular Citrate Fuels Cancer Cell Metabolism and Growth
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.602476
Abstract: Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for… read more here.
Keywords: citrate; cancer cells; cancer cell; cancer ... See more keywords