Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.161
Abstract: Myelin protein zero-like protein 1 (MPZL1) is a member of the immunoglobulin superfamily, and is also a receptor of concanavalin A (ConA). MPZL1 is upregulated in hepatocellular carcinoma (HCC) and accelerates migration of HCC cells.… read more here.
Keywords: protein; zero like; like protein; extracellular domain ... See more keywords
The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.002
Abstract: Cell adhesion between oligodendrocytes and neuronal axons is a critical step for myelination that enables the rapid propagation of action potential in the central nervous system. Here, we show that the transmembrane protein teneurin-4 plays… read more here.
Keywords: extracellular domain; differentiation; adhesion; cell adhesion ... See more keywords
Dynamics of Glutamate Receptor Studied with Single Molecule FRET
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.104
Abstract: NMDA receptors are the main Ca2+ permeable excitatory receptors in the mammalian central nervous system. Glutamate along with glycine binding to the extracellular domain of the receptor leads to activation and upon prolonged exposure to… read more here.
Keywords: glutamate receptor; dynamics glutamate; extracellular domain; receptor ... See more keywords
Expression and purification of the extracellular domain of wild-type humanRET and the dimeric oncogenic mutant C634R.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.290
Abstract: The receptor tyrosine kinase RET is essential in a variety of cellular processes. RET gain-of-function is strongly associated with several cancers, notably multiple endocrine neoplasia type 2A (MEN 2A), while RET loss-of-function causes Hirschsprung's disease… read more here.
Keywords: dimeric oncogenic; extracellular domain; retecd; expression ... See more keywords
Construction of high level prokaryotic expression and purification system of PD-L1 extracellular domain by using Escherichia coli host cell machinery.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.06.004
Abstract: Programmed cell death 1 ligand 1 (PD-L1) is a trans-membrane protein highly expressed on the membrane of cancer cell, which binds inhibitory receptor of PD-1 on the T cells and attenuates anti-tumor immune response.The strategy… read more here.
Keywords: system; escherichia coli; prokaryotic expression; extracellular domain ... See more keywords
Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.03.009
Abstract: CD83 is a type-I membrane protein and an efficient marker for identifying mature dendritic cells. Whereas membrane-bound, full-length CD83 co-stimulates the immune system, a soluble variant (sCD83), consisting of the extracellular domain only, displays strong… read more here.
Keywords: marker; extracellular domain; crystal structure; cd83 ... See more keywords
Expression of 5T4 extracellular domain fusion protein and preparation of anti-5T4 monoclonal antibody with high affinity and internalization efficiency.
Sign Up to like & getrecommendations! Published in 2019 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.07.003
Abstract: 5T4, a membrane protein, is overexpressed in many tumor tissues but rarely expressed in normal tissues. Here, CHO-5T4+ cells were generated and served as the antigen to immunize mice. Hybridoma techniques were employed to produce… read more here.
Keywords: protein; high affinity; anti 5t4; extracellular domain ... See more keywords
Fine epitope mapping of the CD19 extracellular domain promotes design.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00808
Abstract: The B cell surface protein CD19 is present throughout the cell life cycle and uniformly expressed in leukemias making it a target for chimeric antigen receptor engineered immune cell therapy. Identifying the sequence dependence of… read more here.
Keywords: cd19; epitope mapping; antibody; cd19 extracellular ... See more keywords
Tyrosine 51 residue of the syndecan-2 extracellular domain is involved in the interaction with and activation of pro-matrix metalloproteinase-7
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47140-5
Abstract: Although syndecan-2 is known to interact with the matrix metalloproteinase-7 (MMP-7), the details of their interaction were unknown. Our experiments with a series of syndecan-2 extracellular domain deletion mutants show that the interaction is mediated… read more here.
Keywords: mmp; extracellular domain; syndecan extracellular; helix ... See more keywords
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40381
Abstract: Interaction of orthosteric ligands with extracellular domain was described at several aminergic G protein-coupled receptors, including muscarinic acetylcholine receptors. The orthosteric antagonists quinuclidinyl benzilate (QNB) and N-methylscopolamine (NMS) bind to the binding pocket of the… read more here.
Keywords: acetylcholine receptors; acetylcholine; allosteric binding; muscarinic acetylcholine ... See more keywords
Synthesis of the extracellular domain of GLP-1R by chemical and biotechnological approaches
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02784d
Abstract: The extracellular domain of the glucagon-like peptide-1 receptor, GLP-1R, is responsible for the binding of GLP-1, and a handful of additional agonists (such as exenatide, lixisenatide, and liraglutide) used daily for treating type II diabetes… read more here.
Keywords: glp; glp chemical; extracellular domain; domain glp ... See more keywords