Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001590
Abstract: Background Extracellular histones are cytotoxic molecules that are related to cell stress and death. They have been shown to play a crucial role in multiple pathophysiologic processes like sepsis, inflammation, vascular dysfunction, and thrombosis. Their… read more here.
Keywords: machine; death; graft function; graft ... See more keywords
Patients with HBV‐related acute‐on‐chronic liver failure have increased concentrations of extracellular histones aggravating cellular damage and systemic inflammation
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DOI: 10.1111/jvh.12612
Abstract: Acute‐on‐chronic liver failure (ACLF) is the most common type of liver failure and associated with grave consequences. Systemic inflammation has been linked to its pathogenesis and outcome, but the identifiable triggers are absent. Recently, extracellular… read more here.
Keywords: extracellular histones; hbv related; liver failure; systemic inflammation ... See more keywords
Assembly of alternative prothrombinase by extracellular histones initiate and disseminate intravascular coagulation.
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DOI: 10.1182/blood.2019002973
Abstract: Thrombin generation is pivotal to both physiological blood clot formation and pathological development of disseminated intravascular coagulation (DIC). In critical illness, extensive cell damage can release histones into the circulation, which can increase thrombin generation… read more here.
Keywords: coagulation; alternative prothrombinase; prothrombinase; extracellular histones ... See more keywords
Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s363693
Abstract: Introduction Circulating extracellular histones acquire relevance as cytotoxic mediators in sepsis. Extracellular histones act as damage-associated molecular patterns (DAMPs), which induce oxidative stress and NLRP3 inflammasome activation. Inflammasome mediates pyroptosis, a programmed cell death mechanism… read more here.
Keywords: sepsis; pyroptosis; extracellular histones; activation ... See more keywords
Extracellular histones aggravate autoimmune arthritis by lytic cell death
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DOI: 10.3389/fimmu.2022.961197
Abstract: Although recent studies have demonstrated a proinflammatory effect of extracellular histones in sepsis via endothelial cytotoxicity, little is known about their contribution to autoimmune arthritis. Therefore, we investigated the role of extracellular histones in autoimmune… read more here.
Keywords: cytotoxicity; lytic cell; arthritis; extracellular histones ... See more keywords
Endothelial Cells Activated by Extracellular Histones Promote Foxp3+ Suppressive Treg Cells In Vitro
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DOI: 10.3390/ijms23094527
Abstract: Histones are widely recognized as pro-inflammatory mediators upon their release from the nucleus into the extracellular space. However, their impact on endothelial cell immunogenicity is unknown. Endothelial cells, Human Microvascular Endothelial cells 1 (HMEC1), have… read more here.
Keywords: treg; endothelial cells; treg cells; cells vitro ... See more keywords
[Extracellular histones aggravate acute respiratory distress syndrome by inducing peripheral blood mononuclear cells pyroptosis].
Sign Up to like & getrecommendations! Published in 2019 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.issn.2095-4352.2019.11.009
Abstract: OBJECTIVE To explore whether extracellular histones aggravate acute respiratory distress syndrome (ARDS) by inducing peripheral blood mononuclear cell (PBMC) pyroptosis. METHODS Twenty patients with ARDS admitted to Shanghai Pulmonary Hospital, Tongji University School of Medicine… read more here.
Keywords: pyroptosis; group; extracellular histones; expression ... See more keywords